Liu Yujia, Jiang Yanwen, Sun Yongchang
Department of Respiratory and Critical Care Medicine, Peking University Third Hospital; Research Center of Chronic Airway Diseases, Peking University Health Science Center, Beijing, China.
Department of Respiratory and Critical Care Medicine, Peking University International Hospital, Beijing, China.
Expert Rev Respir Med. 2023 Jul-Dec;17(8):735-742. doi: 10.1080/17476348.2023.2257135. Epub 2023 Sep 12.
To investigate whether the prevalence of positive ANA was increased in COPD with interstitial lung abnormality (ILA).
Patients with COPD from 1 September, 2019 to 31 August, 2022 were consecutively enrolled in this cross-sectional study. The characteristics, PFTs, visual assessment of ILA and emphysema on chest CT, and tests for ANA and CRP were recorded for analysis.
In the study period, 100 patients with COPD were enrolled, with 90 (90.0%) males, aging 69.4 ± 8.3 years. ILA was present in 42% ( = 42) of the patients, with subpleural non-fibrotic ILA being the most common pattern. In patients with ILA, the prevalence of positive ANA was higher (45.2%) as compared to those without ILA (13.3%); between whom the difference in D was also significant. In patients with positive ANA, the scores of ILA were higher, while FEV, D, D % predicted, FVC, total lung capacity (TLC), and TLC % predicted were significantly lower, as compared to those with negative ANA.
The presence of ILA in patients with COPD was associated with a higher prevalence of positive ANA. Patients with positive ANA tended to have lower FEV, D and lung volume.
研究慢性阻塞性肺疾病（COPD）合并间质性肺异常（ILA）时抗核抗体（ANA）阳性率是否升高。
连续纳入2019年9月1日至2022年8月31日期间的COPD患者进行这项横断面研究。记录患者的特征、肺功能测试（PFTs）、胸部CT上ILA和肺气肿的视觉评估以及ANA和C反应蛋白（CRP）检测结果进行分析。
在研究期间，纳入了100例COPD患者，其中男性90例（90.0%），年龄69.4±8.3岁。42%（n = 42）的患者存在ILA，胸膜下非纤维化ILA是最常见的类型。与无ILA的患者相比，有ILA的患者中ANA阳性率更高（45.2%）；两者之间的差异也具有统计学意义。与ANA阴性的患者相比，ANA阳性的患者ILA评分更高，而第1秒用力呼气容积（FEV₁）、一氧化碳弥散量（DLCO）、预测DLCO%、用力肺活量（FVC）、肺总量（TLC）和预测TLC%显著更低。
COPD患者中ILA的存在与ANA阳性率较高相关。ANA阳性的患者FEV₁、DLCO和肺容积往往较低。
