Department of Cardiology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Priority Area Chronic Lung Diseases, Research Center Borstel, Borstel, Germany.
BMC Pulm Med. 2024 Oct 10;24(1):506. doi: 10.1186/s12890-024-03311-3.
Interstitial lung abnormality (ILA) has been recognized as a pertinent factor in the development and prognosis of various pulmonary conditions. However, its correlation with co-morbidities remains understudied. The current study endeavors to elucidate the association between ILA and both clinical features and co-morbidities in patients with chronic obstructive pulmonary disease (COPD).
A retrospective cohort comprising 1131 hospitalized patients diagnosed with COPD was examined in this observational study. Patients were dichotomously classified based on the presence or absence of ILA, and subsequent analyses scrutinized disparities in demographic, clinical, and laboratory profiles, alongside co-morbid conditions, between the two subgroups.
Of the 1131 COPD patients, 165 (14.6%) exhibited ILA. No statistically significant differences were discerned between COPD patients with and without ILA concerning demographic, clinical, or laboratory parameters, except for levels of circulating fibrinogen and procalcitonin. Nevertheless, a notable discrepancy emerged in the prevalence of multiple co-morbidities. Relative to COPD patients devoid of ILA, those presenting with ILA manifested a diminished prevalence of lung cancer (OR = 0.50, 95% CI: 0.30-0.83, p = 0.006), particularly of the lung adenocarcinoma (OR = 0.32, 95% CI: 0.15-0.71, p = 0.005). Additionally, the presence of ILA in COPD was positively associated with heart failure (OR = 1.75, 95% CI: 1.04-3.00, p = 0.040) and cancers other than lung cancer (OR = 2.27, 95% CI: 1.16-4.39, p = 0.012).
These findings demonstrate that the presence of ILA is associated with co-morbidities of COPD, particularly lung cancer.
间质性肺异常（ILA）已被认为是各种肺部疾病发生和预后的相关因素。然而，其与合并症的相关性仍研究不足。本研究旨在阐明 ILA 与慢性阻塞性肺疾病（COPD）患者的临床特征和合并症之间的关系。
本观察性研究纳入了 1131 名住院 COPD 患者的回顾性队列。根据是否存在 ILA 将患者分为两组，并对两组间的人口统计学、临床和实验室特征以及合并症情况进行了差异分析。
在 1131 名 COPD 患者中，165 名（14.6%）存在 ILA。除了循环纤维蛋白原和降钙素原水平外，COPD 患者中存在或不存在 ILA 两组间在人口统计学、临床或实验室参数方面无统计学差异。然而，在多种合并症的患病率方面存在显著差异。与不存在 ILA 的 COPD 患者相比，存在 ILA 的患者肺癌（OR=0.50，95%CI：0.30-0.83，p=0.006），特别是肺腺癌（OR=0.32，95%CI：0.15-0.71，p=0.005）的患病率较低。此外，COPD 患者存在 ILA 与心力衰竭（OR=1.75，95%CI：1.04-3.00，p=0.040）和肺癌以外的癌症（OR=2.27，95%CI：1.16-4.39，p=0.012）呈正相关。
这些发现表明，ILA 的存在与 COPD 的合并症相关，特别是肺癌。
