鼻腔给药途径：神经 COVID-19 中针对 SARS-CoV-2 的经鼻脑途径

Intranasal Route: A Nasocerebral Approach against SARS-CoV-2 in NeuroCOVID.

机构信息

Senior Researcher, Lead Scientist COVID-19 and Long-COVID, St. George's Hospital, 83043 Bad Aibling, Germany.

CEO Research and Development, Health-Shield, Vedicinals-9 40764 Langenfeld, Germany.

出版信息

ACS Chem Neurosci. 2023 Oct 4;14(19):3560-3563. doi: 10.1021/acschemneuro.3c00488. Epub 2023 Sep 12.

DOI:10.1021/acschemneuro.3c00488

PMID:37698524

Abstract

The nasal cavity is a prime site for viral load of SARS-CoV-2 in COVID-19, as is evident from the fact that this area has been used for sample collection for the diagnosis of COVID-19. The nasal cavity has a connection with the brain across the cribriform plate which has been reported to be a route of SARS-CoV-2 to the olfactory apparatus and the brain. Targeting the SARS-CoV-2 in the nasal cavity in patients presenting with COVID-19 and long-COVID can result in the prevention and treatment of neurological deficits and therefore needs to be prioritized as a route of potential significance.

摘要

鼻腔是 COVID-19 中 SARS-CoV-2 病毒载量的主要部位，这一点从该区域被用于 COVID-19 诊断的样本采集就可以明显看出。鼻腔通过筛板与大脑相连，据报道，这是 SARS-CoV-2 进入嗅觉器官和大脑的途径。针对 COVID-19 和长 COVID 患者鼻腔中的 SARS-CoV-2，可预防和治疗神经功能缺陷，因此需要优先考虑作为潜在重要途径。