Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.
ACS Chem Neurosci. 2021 Jul 21;12(14):2555-2557. doi: 10.1021/acschemneuro.1c00372. Epub 2021 Jul 6.
Because SARS-CoV-2 uses the nasal cavity as a major route of entry to the human body, nasal administration of drugs and antibodies directed against the virus can prove to be effective for not only pulmonary COVID-19 but also prevention of potential early neuroinvasion caused by this virus. With recent reports of the potential application of antibody-laden nasal spray for the treatment of COVID-19, proposed here is the use of drugs recently proven to be effective against SARS-CoV-2 to be administered via inhalation route using a modified transcribrial device reported previously for its use against , to target SARS-CoV-2 in our fight against COVID-1.
由于 SARS-CoV-2 主要通过鼻腔进入人体，因此针对该病毒的鼻腔内给药的药物和抗体可能不仅对肺部 COVID-19 有效，而且对这种病毒可能引起的早期潜在神经入侵也有效。最近有报道称，含有抗体的鼻腔喷雾剂可能用于治疗 COVID-19，因此本文提出使用最近被证明对 SARS-CoV-2 有效的药物，通过吸入途径给药，使用先前报道过的改良经颅设备，该设备曾用于对抗 SARS-CoV-2，以对抗 COVID-1 中的 SARS-CoV-2。
