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使用超声内镜引导下细针穿刺抽吸/细针活检标本进行肝胆胰癌基因组分析的现状与问题

Current status and issues in genomic analysis using EUS-FNA/FNB specimens in hepatobiliary-pancreatic cancers.

作者信息

Ozono Yoshinori, Kawakami Hiroshi, Uchiyama Naomi, Hatada Hiroshi, Ogawa Souichiro

机构信息

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.

出版信息

J Gastroenterol. 2023 Nov;58(11):1081-1093. doi: 10.1007/s00535-023-02037-z. Epub 2023 Sep 12.

DOI:10.1007/s00535-023-02037-z
PMID:37698719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10590314/
Abstract

Comprehensive genomic profiling based on next-generation sequencing has recently been used to provide precision medicine for various advanced cancers. Endoscopic ultrasound (EUS)-guided fine-needle aspiration (EUS-FNA) and EUS-guided fine-needle biopsy (EUS-FNB) play essential roles in the diagnosis of abdominal masses, mainly pancreatic cancers. In recent years, CGP analysis using EUS-FNA/FNB specimens for hepatobiliary-pancreatic cancers has increased; however, the success rate of CGP analysis is not clinically satisfactory, and many issues need to be resolved to improve the success rate of CGP analysis. In this article, we review the transition from EUS-FNA to FNB, compare each test, and discuss the current status and issues in genomic analysis of hepatobiliary-pancreatic cancers using EUS-FNA/FNB specimens.

摘要

基于新一代测序的综合基因组分析最近已被用于为各种晚期癌症提供精准医疗。超声内镜（EUS）引导下细针穿刺抽吸术（EUS-FNA）和超声内镜引导下细针活检术（EUS-FNB）在腹部肿块（主要是胰腺癌）的诊断中发挥着重要作用。近年来，使用EUS-FNA/FNB标本进行肝胆胰癌的CGP分析有所增加；然而，CGP分析的成功率在临床上并不令人满意，需要解决许多问题以提高CGP分析的成功率。在本文中，我们回顾了从EUS-FNA到FNB的转变，比较了各项检查，并讨论了使用EUS-FNA/FNB标本进行肝胆胰癌基因组分析的现状和问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b03/10590314/27670b81433e/535_2023_2037_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b03/10590314/a511f65bdbdb/535_2023_2037_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b03/10590314/27670b81433e/535_2023_2037_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b03/10590314/a511f65bdbdb/535_2023_2037_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b03/10590314/27670b81433e/535_2023_2037_Fig2_HTML.jpg

相似文献

[1]
Current status and issues in genomic analysis using EUS-FNA/FNB specimens in hepatobiliary-pancreatic cancers.

J Gastroenterol. 2023-11

[2]
Adequacy evaluation and use of pancreatic adenocarcinoma specimens for next-generation sequencing acquired by endoscopic ultrasound-guided FNA and FNB.

Cancer Cytopathol. 2022-4

[3]
Comparison of endoscopic ultrasound-guided fine-needle biopsy versus fine-needle aspiration for genomic profiling and DNA yield in pancreatic cancer: a randomized crossover trial.

Endoscopy. 2021-4

[4]
A Comparative Study of the Diagnostic Utility of Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology (EUS-FNA) versus Endoscopic Ultrasound-Guided Fine Needle Biopsy (EUS-FNB) in Pancreatic and Non-Pancreatic Lesions.

Asian Pac J Cancer Prev. 2022-6-1

[5]
Analysis of Fine-Needle Biopsy vs Fine-Needle Aspiration in Diagnosis of Pancreatic and Abdominal Masses: A Prospective, Multicenter, Randomized Controlled Trial.

Clin Gastroenterol Hepatol. 2017-7-19

[6]
Evaluation of 22G fine-needle aspiration (FNA) versus fine-needle biopsy (FNB) for endoscopic ultrasound-guided sampling of pancreatic lesions: a prospective comparison study.

Surg Endosc. 2018-2-5

[7]
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BMC Gastroenterol. 2015-9-29

[8]
Endoscopic ultrasound with combined fine needle aspiration plus biopsy improves diagnostic yield in solid pancreatic masses.

Scand J Gastroenterol. 2022-5

[9]
Comparison between EUS-guided fine-needle aspiration cytology and EUS-guided fine-needle biopsy histology for the evaluation of pancreatic neuroendocrine tumors.

Pancreatology. 2021-3

[10]
Touch imprint cytology on endoscopic ultrasound fine-needle biopsy provides comparable sample quality and diagnostic yield to standard endoscopic ultrasound fine-needle aspiration specimens in the evaluation of solid pancreatic lesions.

Cytopathology. 2019-3

引用本文的文献

[1]
Comparison of standard auxiliary (contrast or elastography) endoscopic ultrasound-guided fine needle aspiration/biopsy in solid pancreatic lesions: A meta-analysis.

World J Methodol. 2025-9-20

[2]
Unveiling the nature of a peritoneal implant using endoscopic ultrasound.

J Surg Case Rep. 2025-7-24

[3]
Adequacy of EUS-guided fine-needle aspiration and fine-needle biopsy for next-generation sequencing in pancreatic malignancies: A systematic review and meta-analysis.

Endosc Ultrasound. 2024

[4]
Endoscopic Ultrasound-Guided Tissue Sampling for the Cytohistological Diagnosis of Focal Liver Lesions.

Diagnostics (Basel). 2024-5-31

[5]
Is genomic analysis possible in a tissue acquired via endoscopic ultrasound-guided fine-needle biopsy in cholangiocarcinoma?

Clin Endosc. 2024-5

[6]
Oil blotting paper for formalin fixation increases endoscopic ultrasound-guided tissue acquisition-collected sample volumes on glass slides.

Cancer Med. 2024-5

[7]
Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment.

Jpn J Clin Oncol. 2024-3-9

本文引用的文献

[1]
Targeted therapies in advanced biliary tract cancers-a narrative review.

Chin Clin Oncol. 2023-4

[2]
Current Clinical Practice of Precision Medicine Using Comprehensive Genomic Profiling Tests in Biliary Tract Cancer in Japan.

Curr Oncol. 2022-9-30

[3]
Proportion of unresectable pancreatic cancer specimens obtained by endoscopic ultrasound-guided tissue acquisition meeting the OncoGuide™ NCC Oncopanel System analysis suitability criteria: a single-arm, phase II clinical trial.

J Gastroenterol. 2022-12

[4]
Endoscopic Ultrasound-Guided Fine-Needle Biopsy versus Fine-Needle Aspiration in the Diagnosis of Focal Liver Lesions: Prospective Head-to-Head Comparison.

Diagnostics (Basel). 2022-9-13

[5]
Needle Tract Seeding after Endoscopic Ultrasound Tissue Acquisition of Pancreatic Lesions: A Systematic Review and Meta-Analysis.

Diagnostics (Basel). 2022-8-31

[6]
Effect of comprehensive cancer genomic profiling on therapeutic strategies and clinical outcomes in patients with advanced biliary tract cancer: A prospective multicenter study.

Front Oncol. 2022-9-2

[7]
Current options and future directions of systemic therapy for advanced biliary tract cancer.

Explor Target Antitumor Ther. 2021

[8]
Fine-needle biopsy with 19G needle is effective in combination with endoscopic ultrasound-guided tissue acquisition for genomic profiling of unresectable pancreatic cancer.

Dig Endosc. 2023-1

[9]
Genomic mutation characteristics and prognosis of biliary tract cancer.

Am J Transl Res. 2022-7-15

[10]
Liver biopsy technique in the era of genomic cancer therapies: a single-center retrospective analysis.

Int J Clin Oncol. 2022-9

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