内镜超声引导下组织采样用于局灶性肝病变的细胞组织学诊断
Endoscopic Ultrasound-Guided Tissue Sampling for the Cytohistological Diagnosis of Focal Liver Lesions.
作者信息
Lariño-Noia Jose, Jardi-Cuadrado Andrea, Dominguez-Muñoz Juan Enrique, Domínguez-Novoa Yessica, Galego Marco, Rama Alberto, de la Iglesia-Garcia Daniel, Martinez-Seara Xurxo, Abdulkader-Nallib Ihab, Iglesias-Garcia Julio
机构信息
Department of Gastroenterology and Hepatology, Health Research Institute of Santiago de Compostela (IDIS), University Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
Department of Pathology, Health Research Institute of Santiago de Compostela (IDIS), University Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.
出版信息
Diagnostics (Basel). 2024 May 31;14(11):1155. doi: 10.3390/diagnostics14111155.
BACKGROUND
Focal liver lesions (FLL) often require cytohistological evaluation. Endoscopic Ultrasound (EUS)-guided tissue acquisition (EUS-TA) is highly accurate in diagnosing pancreatic and gastrointestinal malignancies. The aim of our study was to evaluate the role of EUS-TA in the characterization of FLL.
METHODS
A retrospective analysis of a prospective database of patients who underwent EUS-TA for the evaluation of FLL. Diagnostic yield, adverse events and factors associated with diagnostic yield were evaluated as endpoints. The effect of variables such as needle size, lesion size, rapid on-site evaluation (ROSE) and the use of cytological or histological needles were analyzed.
RESULTS
A total of 114 cases were included (mean age 68.05 ± 11.35 years, 64 male). A correct diagnosis was made using EUS-TA in 100 of the 114 cases (diagnostic yield of 88%). The EUS-TA of additional extrahepatic lesions during the same EUS procedure increased the diagnostic yield to 94%. No adverse events were reported. Multivariate analysis did not identify any factor influencing the diagnostic yield.
CONCLUSIONS
EUS-TA is a highly accurate and safe technique for the differential diagnosis of FLL and could be considered as the primary approach in this setting.
背景
肝脏局灶性病变（FLL）常需进行细胞组织学评估。内镜超声（EUS）引导下的组织获取（EUS-TA）在诊断胰腺和胃肠道恶性肿瘤方面具有高度准确性。我们研究的目的是评估EUS-TA在FLL特征性诊断中的作用。
方法
对因评估FLL而接受EUS-TA的患者的前瞻性数据库进行回顾性分析。将诊断率、不良事件以及与诊断率相关的因素作为评估终点。分析诸如针的大小、病变大小、快速现场评估（ROSE）以及使用细胞学或组织学针等变量的影响。
结果
共纳入114例患者（平均年龄68.05±11.35岁，男性64例）。114例中的100例通过EUS-TA做出了正确诊断（诊断率为88%）。在同一EUS操作过程中对额外的肝外病变进行EUS-TA可将诊断率提高至94%。未报告不良事件。多因素分析未发现任何影响诊断率的因素。
结论
EUS-TA是一种用于FLL鉴别诊断的高度准确且安全的技术，在这种情况下可被视为主要方法。
Zotero 插件