Department of Chest Diseases, Sisli Hamidiye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Department of Infectious Diseases and Clinical Microbiology, Sisli Hamidiye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
J Infect Dev Ctries. 2023 Aug 31;17(8):1047-1054. doi: 10.3855/jidc.17527.
We aimed to investigate the effects of COVID-19 on patients 24 months after severe COVID-19 pneumonia.
Fifty-four patients with severe COVID-19 pneumonia were evaluated on the 24th month after discharge from the hospital. Spirometry and short form of health-related quality of life scale (SF-36) were used. Chest computed tomography (chest-CT) was performed and the findings were grouped according to lung involvement.
Forced expiratory volume in 1 second (FEV1) % values of 19 patients (35.18%) and forced vital capacity (FVC) % values of 23 patients (42.54%) were found lower than expected on the 24th month. Physical function, energy-vitality, social functionality and general health parameters were found lower than normal on the SF-36 scale. 27 (50.00%) patients had a chest-CT abnormality. There was a correlation between FEV1% and FVC% values and group 3: medium-lower lobe dominant, reticulation + traction, 10-50% surface area. Chest-CT of 6 patients was fully recovered. No correlation was found between chest-CT findings on the 24th month and BMI, length of hospitalization, white blood cell (WBC), lymphocyte, C-reactive protein (CRP), ferritin and D-dimer values at the time of hospitalization.
Functional and radiological abnormalities were detected in a significant number of patients on the 24th month. A systematic monitoring plan must be established to assess and properly manage the long-term problems that may arise.
我们旨在研究 COVID-19 对重症 COVID-19 肺炎患者 24 个月后的影响。
在出院后 24 个月，对 54 例重症 COVID-19 肺炎患者进行评估。使用肺活量计和健康相关生活质量简表（SF-36）进行评估。进行胸部计算机断层扫描（chest-CT），并根据肺部受累情况进行分组。
19 例患者（35.18%）的 1 秒用力呼气量（FEV1）%值和 23 例患者（42.54%）的用力肺活量（FVC）%值在 24 个月时低于预期。SF-36 量表的身体功能、能量活力、社会功能和一般健康参数均低于正常值。27 例（50.00%）患者的 chest-CT 异常。FEV1%和 FVC%值与第 3 组（中下叶为主、网状影+牵拉、10-50%表面积）存在相关性。6 例患者的 chest-CT 完全恢复。24 个月时的 chest-CT 发现与住院时的 BMI、住院时间、白细胞（WBC）、淋巴细胞、C 反应蛋白（CRP）、铁蛋白和 D-二聚体值无相关性。
在第 24 个月时，大量患者存在功能和影像学异常。必须制定系统的监测计划，以评估和妥善处理可能出现的长期问题。
