揭示小细胞肺癌演进的秘密：通过快速尸检获得的新方法和新见解。
Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies.
机构信息
Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Thoracic Surgery, Semmelweis University and National Institute of Oncology, Budapest, Hungary; National Koranyi Institute of Pulmonology, Budapest, Hungary.
Department of Thoracic / Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Cancer Cell. 2023 Sep 11;41(9):1535-1540. doi: 10.1016/j.ccell.2023.08.007.
Abstract
The understanding of small cell lung cancer (SCLC) biology has increased dramatically in recent years, but the processes that allow SCLC to progress rapidly remain poorly understood. Here, we advocate the integration of rapid autopsies and preclinical models into SCLC research as a comprehensive strategy with the potential to revolutionize current treatment paradigms.
摘要
近年来，人们对小细胞肺癌（SCLC）生物学的理解有了显著提高，但允许 SCLC 快速进展的过程仍知之甚少。在这里，我们提倡将快速尸检和临床前模型纳入 SCLC 研究作为一种综合策略，有可能彻底改变当前的治疗模式。
相似文献
1
Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies.揭示小细胞肺癌演进的秘密：通过快速尸检获得的新方法和新见解。
Cancer Cell. 2023 Sep 11;41(9):1535-1540. doi: 10.1016/j.ccell.2023.08.007.
2
Advances in Small-Cell Lung Cancer (SCLC) Translational Research.小细胞肺癌（SCLC）转化研究进展。
Cold Spring Harb Perspect Med. 2021 Apr 1;11(4):a038240. doi: 10.1101/cshperspect.a038240.
3
Small cell lung cancer: where do we go from here?小细胞肺癌：我们从这里何去何从？
Cancer. 2015 Mar 1;121(5):664-72. doi: 10.1002/cncr.29098. Epub 2014 Oct 21.
4
Small cell lung cancer; recent advances of its biology and therapeutic perspective.小细胞肺癌；生物学和治疗前景的最新进展。
Respir Investig. 2022 Mar;60(2):197-204. doi: 10.1016/j.resinv.2021.10.008. Epub 2021 Dec 10.
5
New insights into small-cell lung cancer development and therapy.小细胞肺癌发生发展与治疗的新认识。
Cell Biol Int. 2020 Aug;44(8):1564-1576. doi: 10.1002/cbin.11359. Epub 2020 Apr 18.
6
Recent progress in mapping the emerging landscape of the small-cell lung cancer genome.小细胞肺癌基因组新兴图谱的最新进展。
Exp Mol Med. 2019 Dec 12;51(12):1-13. doi: 10.1038/s12276-019-0349-5.
7
The microRNA expression signature of small cell lung cancer: tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes.小细胞肺癌的微小RNA表达特征：miR-27a-5p和miR-34b-3p的肿瘤抑制因子及其靶向癌基因
J Hum Genet. 2017 Jul;62(7):671-678. doi: 10.1038/jhg.2017.27. Epub 2017 Mar 9.
8
Friend leukemia virus integration 1 promotes tumorigenesis of small cell lung cancer cells by activating the miR-17-92 pathway.Friend白血病病毒整合1通过激活miR-17-92通路促进小细胞肺癌细胞的肿瘤发生。
Oncotarget. 2017 Jun 27;8(26):41975-41987. doi: 10.18632/oncotarget.16715.
9
MicroRNA-138 Regulates DNA Damage Response in Small Cell Lung Cancer Cells by Directly Targeting H2AX.微小RNA-138通过直接靶向H2AX调控小细胞肺癌细胞中的DNA损伤反应。
Cancer Invest. 2015 Apr;33(4):126-36. doi: 10.3109/07357907.2015.1006329. Epub 2015 Feb 20.
10
Small cell lung cancer: will recent progress lead to improved outcomes?小细胞肺癌：近期的进展会带来更好的治疗结果吗？
Clin Cancer Res. 2015 May 15;21(10):2244-55. doi: 10.1158/1078-0432.CCR-14-2958.
引用本文的文献
1
Current and future therapies for small cell lung carcinoma.小细胞肺癌的当前及未来治疗方法
J Hematol Oncol. 2025 Apr 1;18(1):37. doi: 10.1186/s13045-025-01690-6.
2
Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation.揭示强大动力：ASCL1驱动的小细胞肺癌的特征是线粒体数量更多且氧化磷酸化增强。
Cancer Metab. 2025 Mar 31;13(1):16. doi: 10.1186/s40170-025-00382-6.
3
Unveiling the Molecular Features of SCLC With a Clinical RNA Expression Panel.利用临床RNA表达谱揭示小细胞肺癌的分子特征。
JTO Clin Res Rep. 2024 Aug 28;5(11):100723. doi: 10.1016/j.jtocrr.2024.100723. eCollection 2024 Nov.
4
Emerging advances in defining the molecular and therapeutic landscape of small-cell lung cancer.小细胞肺癌分子特征和治疗靶点的新进展。
Nat Rev Clin Oncol. 2024 Aug;21(8):610-627. doi: 10.1038/s41571-024-00914-x. Epub 2024 Jul 4.
5
Small cells - big issues: biological implications and preclinical advancements in small cell lung cancer.小细胞——大问题：小细胞肺癌的生物学意义和临床前进展。
Mol Cancer. 2024 Feb 24;23(1):41. doi: 10.1186/s12943-024-01953-9.
本文引用的文献
1
Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions.小细胞肺癌的临床洞察：肿瘤异质性、诊断、治疗和未来方向。
CA Cancer J Clin. 2023 Nov-Dec;73(6):620-652. doi: 10.3322/caac.21785. Epub 2023 Jun 17.
2
Dynamics of Sequence and Structural Cell-Free DNA Landscapes in Small-Cell Lung Cancer.小细胞肺癌中游离 DNA 序列和结构的动态变化。
Clin Cancer Res. 2023 Jun 13;29(12):2310-2323. doi: 10.1158/1078-0432.CCR-22-2242.
3
A multiplexed in vivo approach to identify driver genes in small cell lung cancer.一种用于鉴定小细胞肺癌中驱动基因的多重体内方法。
Cell Rep. 2023 Jan 31;42(1):111990. doi: 10.1016/j.celrep.2023.111990. Epub 2023 Jan 13.
4
Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer.原型任务将肿瘤内异质性与小细胞肺癌中的可塑性和癌症标志联系起来。
Cell Syst. 2022 Sep 21;13(9):690-710.e17. doi: 10.1016/j.cels.2022.07.006. Epub 2022 Aug 17.
5
cfDNA methylome profiling for detection and subtyping of small cell lung cancers.循环游离 DNA 甲基组谱分析用于小细胞肺癌的检测和亚型分类。
Nat Cancer. 2022 Oct;3(10):1260-1270. doi: 10.1038/s43018-022-00415-9. Epub 2022 Aug 8.
6
Expression patterns and prognostic relevance of subtype-specific transcription factors in surgically resected small-cell lung cancer: an international multicenter study.在手术切除的小细胞肺癌中，亚型特异性转录因子的表达模式和预后相关性：一项国际多中心研究。
J Pathol. 2022 Aug;257(5):674-686. doi: 10.1002/path.5922. Epub 2022 May 25.
7
Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer.人类小细胞肺癌图谱中的可塑性、转移和免疫抑制特征。
Cancer Cell. 2021 Nov 8;39(11):1479-1496.e18. doi: 10.1016/j.ccell.2021.09.008. Epub 2021 Oct 14.
8
Genomic and Transcriptomic Characterization of Relapsed SCLC Through Rapid Research Autopsy.通过快速研究尸检对复发性小细胞肺癌进行基因组和转录组特征分析。
JTO Clin Res Rep. 2021 Mar 11;2(4):100164. doi: 10.1016/j.jtocrr.2021.100164. eCollection 2021 Apr.
9
Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer.单细胞分析揭示小细胞肺癌发生治疗抵抗后肿瘤内异质性增加。
Nat Cancer. 2020 Apr;1:423-436. doi: 10.1038/s43018-019-0020-z. Epub 2020 Feb 17.
10
Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities.转录因子程序和免疫途径激活模式定义了具有不同治疗弱点的 SCLC 的四个主要亚型。
Cancer Cell. 2021 Mar 8;39(3):346-360.e7. doi: 10.1016/j.ccell.2020.12.014. Epub 2021 Jan 21.
Zotero 插件