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帕金森病中深静脉血栓形成的发生率。

The incidence of deep venous thrombosis in Parkinson's disease.

作者信息

Afsin Emine, Coşgun Zeliha, Kurul Ramazan, Türkoğlu Şule Aydın

机构信息

Department of Chest Diseases, Bolu Abant Izzet Baysal Unıversıty, Bolu, Turkey.

Department of Radiodiagnostics, Medical School, Bolu Abant Izzet Baysal University, Bolu, Turkey.

出版信息

Neurol Res. 2023 Nov;45(11):1050-1054. doi: 10.1080/01616412.2023.2257441. Epub 2023 Sep 12.

Abstract

INTRODUCTION

Venous thromboembolism is one of the causes of sudden death in Parkinson's Disease (PD). Few studies have investigated the correlation between PD and deep venous thrombosis (DVT). This study aimed to investigate the frequency of DVT in PD patients prospectively.

MATERIAL AND METHOD

Demographic characteristics of 37 PD patients without known risk factors for DVT, disease duration, Hoehn-Yahr (H - Y) stage, oxygen saturation (SpO2) and heart rate values with pulse oximetry, use of assistive devices, waist and knee circumference measurements, and modified Medical Research Council (mMRC) dyspnea score was recorded. Both legs were evaluated for thrombus by Doppler venous ultrasound (US).

RESULTS

With the H-Y stage of the disease duration, a positive correlation was determined between the H-Y stage and mMRC. Disease duration was negatively correlated with BMI and positively correlated with the need for assistance. Assistive device use was positively associated with age and mMRC. DVT was detected in only one patient. When our patients' files were reviewed after 1.5 years, one patient was hospitalized with the diagnosis of submassive pulmonary embolism.

CONCLUSION

Attention should be paid to the development of DVT in elderly patients with advanced stages of PD, progression in the H-Y stage, use of assistive devices, and progression in dyspnea scoring. There is also a need for studies on the benefit of DVT prophylaxis in PD patients with a high risk of venous thromboembolism.

摘要

引言

静脉血栓栓塞是帕金森病(PD)患者猝死的原因之一。很少有研究调查PD与深静脉血栓形成(DVT)之间的相关性。本研究旨在前瞻性地调查PD患者中DVT的发生率。

材料与方法

记录37例无已知DVT危险因素的PD患者的人口统计学特征、病程、 Hoehn-Yahr(H-Y)分期、经脉搏血氧饱和度测定的血氧饱和度(SpO2)和心率值、辅助设备的使用情况、腰围和膝围测量值以及改良医学研究委员会(mMRC)呼吸困难评分。通过多普勒静脉超声(US)对双腿进行血栓评估。

结果

随着病程的H-Y分期,H-Y分期与mMRC之间呈正相关。病程与体重指数呈负相关,与对辅助的需求呈正相关。辅助设备的使用与年龄和mMRC呈正相关。仅在1例患者中检测到DVT。在1.5年后复查我们患者的病历档案时,1例患者因亚大块肺栓塞诊断住院。

结论

对于晚期PD老年患者、H-Y分期进展、辅助设备的使用以及呼吸困难评分进展,应关注DVT的发生。对于静脉血栓栓塞高风险的PD患者,也需要开展关于DVT预防益处的研究。

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