School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China.
School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
Cells. 2024 Nov 13;13(22):1874. doi: 10.3390/cells13221874.
Parkinson's disease (PD), a prevalent neurodegenerative disorder characterized by dopaminergic neuron degeneration and α-synuclein accumulation, has been increasingly associated with coagulation dysfunction. This review synthesizes emerging evidence linking dysregulated coagulation to PD pathophysiology. We examine the alterations in coagulation parameters, including elevated fibrinogen levels, impaired fibrinolysis, and platelet dysfunction, which collectively contribute to a hypercoagulable state in PD patients. Epidemiological studies have revealed a higher incidence of thrombotic events, such as deep vein thrombosis (DVT) and stroke, among PD patients, suggesting significant comorbidity between PD and coagulation disorders. This review explores the potential pathophysiological mechanisms underlying this association, focusing on the roles of inflammation and oxidative stress. Additionally, we discuss the limitations of current research and propose future directions. This comprehensive analysis underscores the importance of understanding the coagulation-neurodegeneration axis in PD, which may lead to novel diagnostic and therapeutic strategies for this debilitating condition.
帕金森病（PD）是一种常见的神经退行性疾病，其特征是多巴胺能神经元退化和α-突触核蛋白积累，与凝血功能障碍的关系日益密切。本综述综合了将失调的凝血与 PD 病理生理学联系起来的新证据。我们检查了凝血参数的变化，包括纤维蛋白原水平升高、纤维蛋白溶解受损和血小板功能障碍，这些共同导致 PD 患者处于高凝状态。流行病学研究表明，PD 患者深静脉血栓形成（DVT）和中风等血栓事件的发生率更高，这表明 PD 和凝血障碍之间存在显著的合并症。本综述探讨了这种关联的潜在病理生理学机制，重点关注炎症和氧化应激的作用。此外，我们还讨论了当前研究的局限性，并提出了未来的方向。这项全面的分析强调了理解 PD 中凝血-神经退行性变轴的重要性，这可能为这种衰弱性疾病带来新的诊断和治疗策略。
