Ball Memorial Transitional Year Program, Indiana University School of Medicine, Muncie, IN, USA
Department of Family Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
BMJ Case Rep. 2023 Sep 12;16(9):e253023. doi: 10.1136/bcr-2022-253023.
COVID-19 infection and hereditary haemochromatosis (HH) have something in common; the disease course can be monitored with ferritin levels. Throughout the pandemic, physicians have looked for markers to help predict disease severity. Ferritin levels are commonly used to predict and monitor disease severity in hospitalised patients with COVID-19. While ferritin is elevated as part of the acute-phase reaction in response to infection, it can also be elevated due to iron overload. We report a case of undiagnosed, asymptomatic HH that was unveiled after COVID-19 infection via monitoring for resolution of ferritin levels that were found to be extremely elevated during a moderate COVID-19 infection. This diagnosis allowed the patient to initiate phlebotomy treatment before symptoms of HH arose.
COVID-19 感染和遗传性血色素沉着症（HH）有一些共同之处；疾病过程可以通过铁蛋白水平监测。在整个大流行期间，医生一直在寻找标志物来帮助预测疾病的严重程度。铁蛋白水平通常用于预测和监测 COVID-19 住院患者的疾病严重程度。虽然铁蛋白升高是感染后急性期反应的一部分，但也可能因铁过载而升高。我们报告了一例未确诊的无症状 HH 病例，该病例是在 COVID-19 感染后通过监测铁蛋白水平的恢复情况而发现的，在中度 COVID-19 感染期间，铁蛋白水平极高。这一诊断使患者在 HH 症状出现之前就开始接受放血治疗。
