Cen Xia, Cheng Si-Yu, Shi Zong-Min, Xie Zhuo-Hong, Zhang Ling-Ling, Yang Bin, Ying Guang-Guo
Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety, School of Environment, South China Normal University, Guangzhou 510006, China.
Huan Jing Ke Xue. 2023 Sep 8;44(9):5017-5024. doi: 10.13227/j.hjkx.202209221.
Antibiotic contamination in drinking water has attracted widespread attention. The pollution condition of six macrolide antibiotics (erythromycin-H[KG-*2/5]O, clarithromycin, oleandomycin, roxithromycin, leucomycin, and tylosin) in two drinking water treatment plants was monitored, and the reaction mechanism of tylosin, a typical macrolide antibiotic, during chlorination disinfection treatment was investigated. The results showed that the six macrolide antibiotics can be widely detected in the drinking water treatment processes; however, their concentrations were generally very low. The concentrations of macrolide antibiotics in the influents and effluents ranged from 0.18 ng·L to 3.97 ng·L and 0.02 ng·L to 1.91 ng·L, respectively. The removal rates of the six macrolides in the drinking water treatment were different, ranging from 18% (oleandomycin) to 100% (erythromycin- H[KG-*2/5]O). The degradation of the six macrolides during chlorination was slow and greatly affected by water quality parameters. The chlorination degradation of tylosin followed the second-order reaction kinetic mode, with the kinetic rate constant of 0.77 L·(mol·s) at pH 7.0. Nine chlorination degradation products of tylosin were detected, and the reaction pathways primarily included tertiary amine hydroxylation, aromatic oxidation, and epoxy addition.
饮用水中的抗生素污染已引起广泛关注。监测了两家饮用水处理厂中六种大环内酯类抗生素（红霉素-H₂O、克拉霉素、竹桃霉素、罗红霉素、柱晶白霉素和泰乐菌素）的污染状况，并研究了典型大环内酯类抗生素泰乐菌素在氯化消毒处理过程中的反应机制。结果表明，六种大环内酯类抗生素在饮用水处理过程中均可被广泛检测到；然而，它们的浓度普遍很低。大环内酯类抗生素在进水和出水中的浓度分别为0.18 ng·L至3.97 ng·L和0.02 ng·L至1.91 ng·L。六种大环内酯类抗生素在饮用水处理中的去除率各不相同，范围为18%（竹桃霉素）至100%（红霉素-H₂O）。六种大环内酯类抗生素在氯化过程中的降解缓慢，且受水质参数影响较大。泰乐菌素的氯化降解遵循二级反应动力学模式，在pH 7.0时动力学速率常数为0.77 L·(mol·s)。检测到泰乐菌素的九种氯化降解产物，反应途径主要包括叔胺羟基化、芳环氧化和环氧加成。
