Medical Communication and Psychosomatic Medicine, University Hospital Basel, Klingelbergstrasse 23, 4031, Basel, Switzerland.
Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
Sci Rep. 2023 Sep 12;13(1):15081. doi: 10.1038/s41598-023-41984-8.
The red blood cell distribution width (RDW) is a routinely available blood marker that measures the variation of the size/volume of red blood cells. The aim of our study was to investigate the prognostic value of RDW in cardiac arrest patients and to assess whether RDW improves the prognostic value of three cardiac arrest-specific risk scores. Consecutive adult cardiac arrest patients admitted to the ICU of a Swiss university hospital were included. The primary outcome was poor neurological outcome at hospital discharge assessed by Cerebral Performance Category. Of 702 patients admitted to the ICU after cardiac arrest, 400 patients (57.0%) survived, of which 323 (80.8%) had a good neurological outcome. Higher mean RDW values showed an independent association with poor neurological outcomes at hospital discharge (adjusted OR 1.27, 95% CI 1.14 to 1.41; p < 0.001). Adding the maximum RDW value to the OHCA- CAHP- and PROLOGUE cardiac arrest scores improved prognostic performance. Within this cohort of cardiac arrest patients, RDW was an independent outcome predictor and slightly improved three cardiac arrest-specific risk scores. RDW may therefore support clinical decision-making.
红细胞分布宽度（RDW）是一种常规的血液标志物，用于测量红细胞大小/体积的变化。我们的研究目的是探讨 RDW 在心脏骤停患者中的预后价值，并评估 RDW 是否能提高三种心脏骤停特异性风险评分的预后价值。连续纳入瑞士大学医院 ICU 收治的成年心脏骤停患者。主要结局为出院时通过脑功能预后评分（Cerebral Performance Category）评估的不良神经结局。在心脏骤停后入住 ICU 的 702 例患者中，400 例（57.0%）存活，其中 323 例（80.8%）神经功能良好。较高的平均 RDW 值与出院时不良神经结局独立相关（调整后的 OR 1.27，95%CI 1.14 至 1.41；p<0.001）。将最大 RDW 值添加到 OHCA-CAHP 和 PROLOGUE 心脏骤停评分中可提高预后性能。在这组心脏骤停患者中，RDW 是独立的预后预测指标，略微改善了三种心脏骤停特异性风险评分。因此，RDW 可能有助于临床决策。
