Formation of didesmethylethimizol (4-5-dicarbamoyl-1-ethylimidazole) in man.
作者信息
Piotrovsky L B, Soltés L, Stefek M, Trnovec T
出版信息
Eur J Drug Metab Pharmacokinet. 1986 Apr-Jun;11(2):87-9. doi: 10.1007/BF03189832.
PMID:3770018
Abstract
The chemical structure of an ethimizol metabolite found earlier in human urine and saliva was established as 4,5-dicarbamoyl-1-ethylimidazole (didesmethylethimizol). The treatment of biological samples comprised a solid-phase extraction, high-performance thin-layer chromatographic separation and high-performance liquid chromatographic purification techniques. The identification of the metabolite was based on the comparison of a mass spectrum of the substance isolated from the biological fluid with the mass spectra of synthetised reference compounds.
摘要
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本文引用的文献
1
Monitoring of ethimizol and its metabolites in serum or saliva by means of high-performance liquid chromatography.
J Chromatogr. 1983 Mar 11;273(1):213-6. doi: 10.1016/s0378-4347(00)80941-x.
2
[The pharmacology of memory (results and prospects)].[记忆的药理学（结果与展望）]
Fiziol Zh SSSR Im I M Sechenova. 1984 Jul;70(7):983-9.
3
Demethylation in vivo of a xanthine-related respiratory analeptic, ethimizol.一种与黄嘌呤相关的呼吸兴奋剂乙胺噻唑在体内的去甲基化作用。
Xenobiotica. 1983 Nov;13(11):683-7. doi: 10.3109/00498258309052229.
4
Determination of ethimizol and two of its metabolites in serum by high-pressure liquid chromatography.用高压液相色谱法测定血清中的乙嘧唑及其两种代谢物。
Pharmacology. 1983;26(4):198-204. doi: 10.1159/000137802.
5
Pharmacokinetics of ethimizol in man.
Pharmazie. 1985 Jun;40(6):410-1.
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