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[记忆的药理学(结果与展望)]

[The pharmacology of memory (results and prospects)].

作者信息

Borodkin Iu S, Zaĭtsev Iu V

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1984 Jul;70(7):983-9.

PMID:6208060
Abstract

Principal possibilities and limits of using the pharmacological approach for control of memory in studies of neurophysiological and neurochemical mechanisms of learning and memory in humans and animals are reviewed as well as its place in experimental and clinical therapy of memory disorders. Using an unspecific connector aethimizol as a pharmacological probe aided to assess changes accompanying the formation and consolidation of memory traces. The significance of fast and slow bioelectrical brain activity in the memory processing, the role of enzymes involved in transcription and template chromatine activity of the neurons under the effect of drugs on memory and learning, the correlation between time-depending learning and the pattern of RNA synthesis in brain cells, as well as possibilities and pathways of utilization of drugs in the correction of the long-term memory matrix formed by a stable pathological state of the brain, are discussed.

摘要

综述了在人类和动物学习与记忆的神经生理和神经化学机制研究中,使用药理学方法控制记忆的主要可能性和局限性,以及其在记忆障碍实验和临床治疗中的地位。使用非特异性连接剂乙硫异烟胺作为药理学探针,有助于评估记忆痕迹形成和巩固过程中伴随的变化。讨论了快速和慢速脑生物电活动在记忆处理中的意义、药物对记忆和学习产生影响时,参与神经元转录和模板染色质活性的酶的作用、随时间变化的学习与脑细胞中RNA合成模式之间的相关性,以及利用药物纠正由大脑稳定病理状态形成的长期记忆基质的可能性和途径。

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