Jo Jaeyeop, Son Mingyun, Chae Yeon, Yun Taesik, Koo Yoonhoi, Lee Dohee, Kang Hyun-Gu, Kang Byeong-Teck, Yang Mhan-Pyo, Kim Hakhyun
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, 28644, Chungbuk, Republic of Korea.
College of Veterinary Medicine, Kyungpook National University, Daegu, 41566, Republic of Korea.
Ir Vet J. 2023 Sep 13;76(1):23. doi: 10.1186/s13620-023-00252-x.
To the best of our knowledge, this is the first report of female genital system infiltration of T-cell lymphoma in veterinary literature.
A 1.5-year-old, intact female Golden Retriever was referred due to melena and hyporexia that lasted for three weeks. Fever (40.5℃), tachycardia, tachypnoea, pale mucous membranes, and purulent vaginal discharge were identified on physical examination. Blood analyses revealed leucocytosis, anaemia, hypoalbuminemia, and increased lactate and C-reactive protein levels. On abdominal radiography, the small intestine was moderately deviated because of an oval-shaped mass (13 cm × 8.7 cm) located in the mid-abdomen. An enlarged tubular-shaped structure that had the opacity of soft tissue located in dorsal to the bladder to the middle of the abdomen, and an oval-shaped mass (5.28 cm × 3.26 cm), which was suspected to be a medial iliac lymph node located at the sixth to seventh lumbar level. Abdominal ultrasonography revealed gas and fluid in the lumen of the uterine horn with a severely thickened wall, round enlarged lymph nodes around the genitourinary system, and free fluid in the abdominal cavity. Based on these results, pyometra was suspected, and an exploratory laparotomy was performed for ovariohysterectomy. The resected ovary and uterus were macroscopically hypertrophied. Histopathological examination of the ovary and uterus revealed neoplastic proliferation of large round cells with strong immunoreactivity for CD3, indicating T-cell lymphoma. Therefore, the young dog was diagnosed with genital lymphoma.
The present report describes T-cell lymphoma infiltrating the uterus and ovaries in a young dog, which is rarely diagnosed and could aid in the differential diagnosis of genital diseases in young dogs.
据我们所知，这是兽医文献中首例关于T细胞淋巴瘤浸润雌性生殖系统的报告。
一只1.5岁、未绝育的雌性金毛猎犬因持续三周的黑便和食欲减退前来就诊。体格检查发现发热（40.5℃）、心动过速、呼吸急促、黏膜苍白以及脓性阴道分泌物。血液分析显示白细胞增多、贫血、低白蛋白血症以及乳酸和C反应蛋白水平升高。腹部X线摄影显示，由于位于中腹部的椭圆形肿块（13 cm×8.7 cm），小肠中度移位。在膀胱背侧至腹部中部有一个增大的管状结构，其密度与软组织相同，还有一个椭圆形肿块（5.28 cm×3.26 cm），怀疑是位于第六至七腰椎水平的髂内淋巴结。腹部超声检查显示子宫角腔内有气体和液体，子宫壁严重增厚，泌尿生殖系统周围有圆形肿大淋巴结，腹腔内有游离液体。基于这些结果，怀疑患有子宫蓄脓，并进行了剖腹探查术以切除卵巢子宫。切除的卵巢和子宫肉眼可见肥大。卵巢和子宫的组织病理学检查显示大圆形细胞的肿瘤性增殖，对CD3有强烈免疫反应，提示为T细胞淋巴瘤。因此，这只幼犬被诊断为生殖系统淋巴瘤。
本报告描述了一只幼犬发生的T细胞淋巴瘤浸润子宫和卵巢，这种情况很少被诊断出来，有助于对幼犬生殖系统疾病进行鉴别诊断。
