根据世界卫生组织的分类，对 171 例犬和猫非霍奇金淋巴瘤进行组织病理学分类。

Histopathologic classification of 171 cases of canine and feline non-Hodgkin lymphoma according to the WHO.

机构信息

Department of Veterinary Public Health and Animal Pathology, Pathological Anatomy Service Alma Mater Studiorum-University of Bologna, Italy.

出版信息

Vet Comp Oncol. 2010 Mar;8(1):38-49. doi: 10.1111/j.1476-5829.2009.00201.x.

DOI:10.1111/j.1476-5829.2009.00201.x

PMID:20230580

Abstract

A retrospective collection of 171 lymphoid neoplasms (123 dogs and 48 cats) was classified according to the Revised European-American Lymphoma (REAL) classification, adopted in 2002 by the World Health Organization (WHO), to evaluate the WHO system for categorization of canine and feline neoplasms. Microscopic examination was performed after standard hematoxylin-eosin staining and immunohistochemical labelling for B (CD79a) or T (CD3) cell phenotypes. B-cell lymphomas were prevalent in dogs and T-cell lymphomas in cats. B-Large cell lymphoma (B-LCL) frequently showed plasmacytoid differentiation; notably, two canine plasma cell tumours (PCT) expressed both CD79 and CD3. There were difficulties in differentiating B-lymphoblastic lymphoma (B-LBL) from Burkitt-type lymphoma. Furthermore, intestinal T-cell lymphoma (ITCL) exhibited a huge morphologic variability. Finally, multicentric mature small and thymic T-cell lymphomas were diagnosed, although these categories are not codified by the WHO classification.

摘要

回顾性收集了 171 例淋巴肿瘤（123 只狗和 48 只猫），根据 2002 年世界卫生组织（WHO）采用的修订后的欧洲-美洲淋巴瘤（REAL）分类进行分类，以评估 WHO 犬和猫肿瘤分类系统。对常规苏木精-伊红染色和 B（CD79a）或 T（CD3）细胞表型的免疫组织化学标记后进行了显微镜检查。B 细胞淋巴瘤在狗中较为常见，T 细胞淋巴瘤在猫中较为常见。B-大细胞淋巴瘤（B-LCL）常表现出浆细胞样分化；值得注意的是，有两例犬浆细胞瘤（PCT）同时表达 CD79 和 CD3。B-淋巴母细胞淋巴瘤（B-LBL）与伯基特型淋巴瘤的鉴别存在困难。此外，肠 T 细胞淋巴瘤（ITCL）表现出巨大的形态学可变性。最后，诊断出多中心成熟小 T 细胞淋巴瘤和胸腺瘤，尽管这些类别未被 WHO 分类编码。