Epidemiology Section, Division of Public Health, Osaka Institute of Public Health, Osaka, Japan.
Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan.
J Physiol Anthropol. 2023 Sep 12;42(1):21. doi: 10.1186/s40101-023-00338-z.
Height loss starting in middle age was previously shown to be associated with high cardiovascular mortality in later life. However, the factors associated with height loss remain unknown. Since low serum albumin levels are reported to be associated with high mortality caused by cardiovascular disease, they may also contribute to height loss.
To clarify the association between serum albumin and height loss, we conducted a retrospective study of 7637 Japanese workers who participated in general health check-ups from 2008 to 2019. Height loss was defined as the highest quartile of height loss per year.
Individual with high serum concentration of albumin possess beneficial influence on preventing incidence of height loss. In both men and women, serum albumin level was significantly inversely associated with height loss. After adjustment for known cardiovascular risk factors, the adjusted odd ratio (OR) and 95% confidence interval (CI) for height loss per 1 standard deviation of albumin (0.2 g/dL for both men and women) were 0.92 (0.86, 0.98) in men and 0.86 (0.79, 0.95) in women. Even when the analysis was limited to participants without hypoalbuminemia, essentially same association was observed, with fully adjusted corresponding ORs (95%CI) of 0.92 (0.86, 0.98) in men and 0.86 (0.78, 0.94) in women.
Independent of known cardiovascular risk factors, higher serum albumin levels may prevent height loss among Japanese workers. While several different diseases cause hypoalbuminemia, they may not be the main reasons for the association between serum albumin and height loss. Though further research is necessary, this finding may help clarify the mechanisms underlying the association between height loss and higher mortality in later life.
中年开始的身高下降此前被证明与晚年高心血管死亡率有关。然而，与身高下降相关的因素仍不清楚。由于低血清白蛋白水平与心血管疾病导致的高死亡率有关，它们也可能导致身高下降。
为了阐明血清白蛋白与身高下降之间的关系，我们对 2008 年至 2019 年参加一般健康检查的 7637 名日本工人进行了回顾性研究。身高下降定义为每年身高下降的最高四分位。
个体血清白蛋白浓度高对预防身高下降有有益影响。在男性和女性中，血清白蛋白水平与身高下降呈显著负相关。在调整已知心血管危险因素后，白蛋白每标准差（男性和女性均为 0.2 g/dL）的身高下降调整比值比（OR）和 95%置信区间（CI）分别为男性 0.92（0.86，0.98）和女性 0.86（0.79，0.95）。即使在分析仅限于没有低白蛋白血症的参与者时，也观察到了基本相同的关联，男性完全调整后的相应 OR（95%CI）为 0.92（0.86，0.98），女性为 0.86（0.78，0.94）。
独立于已知心血管危险因素，较高的血清白蛋白水平可能会预防日本工人的身高下降。虽然有几种不同的疾病会导致低白蛋白血症，但它们可能不是血清白蛋白与身高下降之间关联的主要原因。尽管还需要进一步研究，但这一发现可能有助于阐明身高下降与晚年更高死亡率之间关联的机制。
