老年人的动脉粥样硬化与身高下降之间的关系。
Association between atherosclerosis and height loss among older individuals.
机构信息
Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan.
Epidemiology Section, Division of Public Health, Osaka Institute of Public Health, Osaka, 537-0025, Japan.
出版信息
Sci Rep. 2024 Apr 2;14(1):7776. doi: 10.1038/s41598-024-57620-y.
Atherosclerosis and height loss are each reportedly associated with cardiovascular disease. However, no studies have found an association between atherosclerosis and height loss. A retrospective study of 2435 individuals aged 60-89 years who underwent annual health check-ups was conducted. Atherosclerosis was defined as carotid intima-media thickness (CIMT) ≥ 1.1 mm. Height loss was defined as being in the highest quintile of height decrease per year, as in our previous studies. Among study participants, 555 were diagnosed as having atherosclerosis. Independent of known cardiovascular risk factors, atherosclerosis was positively associated with height loss. The adjusted odds ratio (OR) was 1.46 (95% confidence interval, 1.15, 1.83). Essentially the same associations were observed for men and women. The adjusted OR (95% CI) was 1.43 (1.01, 2.04) for men and 1.46 (1.07, 1.99) for women. Among older individuals, atherosclerosis is associated with height loss. This result can help clarify the mechanism underlying the association between height loss and cardiovascular disease.
动脉粥样硬化和身高下降均与心血管疾病相关。然而，目前尚无研究发现动脉粥样硬化与身高下降之间存在关联。本研究对 2435 名年龄在 60-89 岁之间、每年进行健康检查的个体进行了回顾性研究。动脉粥样硬化定义为颈动脉内膜中层厚度（CIMT）≥1.1mm。身高下降定义为每年身高下降幅度处于最高五分位数，与我们之前的研究相同。在研究参与者中，有 555 人被诊断为患有动脉粥样硬化。在排除已知心血管危险因素后，动脉粥样硬化与身高下降呈正相关。调整后的比值比（OR）为 1.46（95%置信区间，1.15，1.83）。男性和女性均观察到基本相同的关联。男性调整后的 OR（95%CI）为 1.43（1.01，2.04），女性为 1.46（1.07，1.99）。在老年人中，动脉粥样硬化与身高下降相关。这一结果有助于阐明身高下降与心血管疾病之间关联的潜在机制。
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