Noninvasive Cardiovascular Imaging Section, Cardiovascular Division, Department of Medicine and Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Eur Heart J. 2023 Dec 1;44(45):4738-4747. doi: 10.1093/eurheartj/ehad510.
Cardiac magnetic resonance offers multiple facets in the diagnosis, risk stratification, and management of patients with myocardial diseases. Particularly, its feature to precisely monitor disease activity lends itself to quantify response to novel therapeutics. This review critically appraises the value of cardiac magnetic resonance imaging biomarkers as surrogate endpoints for prospective clinical trials. The primary focus is to comprehensively outline the value of established cardiac magnetic resonance parameters in myocardial diseases. These include heart failure, cardiac amyloidosis, iron overload cardiomyopathy, hypertrophic cardiomyopathy, cardio-oncology, and inflammatory cardiomyopathies like myocarditis and sarcoidosis.
心脏磁共振在心肌疾病的诊断、风险分层和管理方面提供了多个方面。特别是，它精确监测疾病活动的功能使其能够量化对新型治疗方法的反应。这篇综述批判性地评估了心脏磁共振成像生物标志物作为前瞻性临床试验替代终点的价值。主要重点是全面概述心脏磁共振参数在心肌疾病中的价值。这些包括心力衰竭、心脏淀粉样变性、铁过载心肌病、肥厚型心肌病、心脏肿瘤学以及心肌炎和肉样瘤等炎症性心肌病。
