Shan Peng, Dong Hang, Li Shilan
Department of Laboratory, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, People's Republic of China.
Core Unit of National Clinical Research Center for Laboratory Medicine, Hefei, Anhui, 230036, People's Republic of China.
J Blood Med. 2023 Sep 6;14:513-517. doi: 10.2147/JBM.S412837. eCollection 2023.
Acute basophilic leukemia (ABL) arising from chronic myeloid leukemia (CML) with abundant mast cells (MCs), coexisting with a complex karyotype is rare. Here, we report an 81-year-old man admitted to our hospital with a history of ABL. He was diagnosed with CML in the chronic phase in January 2018, and Imatinib was used at a daily dose of 400mg. Then, transformation to ABL with abundant MCs in the bone marrow and complex karyotypes including 48,XY, trisomy 8 (+8), isochromosome 17(q10) [i(17)(q10)], and derivative chromosome 22 t(9;22) [der(22)t(9;22)] were discovered simultaneously in January 2022. In conclusion, the increased number of MCs in our case is a reminder that they might play an important role in the prognosis of CML and trigger the development of complex karyotypes. Moreover, this is the first case report of ABL arising from CML with abundant MCs, coexisting with 48,XY, +8, i(17)(q10), and der(22)t(9;22), during Imatinib treatment. Further studies are needed to better characterize this rare condition.
由慢性髓系白血病（CML）引发的急性嗜碱性粒细胞白血病（ABL），伴有大量肥大细胞（MCs），且同时存在复杂核型，这种情况较为罕见。在此，我们报告一名81岁男性因ABL病史入院。他于2018年1月被诊断为慢性期CML，并使用伊马替尼，每日剂量为400mg。随后，在2022年1月同时发现骨髓中出现大量MCs的ABL转化，以及包括48,XY,三体8（+8）、等臂染色体17（q10）[i(17)(q10)]和衍生染色体22 t(9;22) [der(22)t(9;22)]的复杂核型。总之，我们病例中MCs数量的增加提示它们可能在CML的预后中起重要作用，并引发复杂核型的发展。此外，这是首例关于伊马替尼治疗期间由CML引发的ABL病例报告，伴有大量MCs，同时存在48,XY, +8, i(17)(q10)和der(22)t(9;22)。需要进一步研究以更好地描述这种罕见情况。
