Peterson L C, Parkin J L, Arthur D C, Brunning R D
Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, Minneapolis, Minnesota 55415.
Am J Clin Pathol. 1991 Aug;96(2):160-70. doi: 10.1093/ajcp/96.2.160.
The authors describe eight cases of acute basophilic leukemia. In six of the eight cases, basophilic involvement was not apparent by light microscopic examination. The cases were identified on the basis of ultrastructural evidence for basophil/mast cell differentiation of the blasts with little or no differentiation into other lineages. Ultrastructural analysis revealed immature basophil granules in blasts in all eight cases and theta granules in blasts in four cases. In three cases, ultrastructural evidence of mast cell differentiation also was present, with rare cells showing evidence for both basophil and mast cell differentiation. No clinical features distinguished this group of patients from others with acute myeloid leukemia. Cytogenetically, the cases were heterogeneous. Three had a Philadelphia chromosome; none had a t(6;9). The authors conclude that ultrastructural analysis usually must be used to diagnose acute basophilic leukemia, that acute basophilic leukemia is associated frequently with the Philadelphia chromosome, and that the ultrastructural findings provide evidence for a common origin of basophils and mast cells.
作者描述了8例急性嗜碱性粒细胞白血病病例。在这8例中的6例中，嗜碱性粒细胞浸润在光学显微镜检查下并不明显。这些病例是根据原始细胞嗜碱性粒细胞/肥大细胞分化的超微结构证据来确定的，原始细胞很少或没有分化为其他谱系。超微结构分析显示，所有8例原始细胞中均有未成熟的嗜碱性粒细胞颗粒，4例原始细胞中有θ颗粒。3例中还存在肥大细胞分化的超微结构证据，罕见细胞同时显示嗜碱性粒细胞和肥大细胞分化的证据。没有临床特征能将这组患者与其他急性髓系白血病患者区分开来。细胞遗传学方面，这些病例具有异质性。3例有费城染色体；均无t(6;9)。作者得出结论，通常必须使用超微结构分析来诊断急性嗜碱性粒细胞白血病，急性嗜碱性粒细胞白血病常与费城染色体相关，并且超微结构发现为嗜碱性粒细胞和肥大细胞的共同起源提供了证据。
