[Age-related changes in hematological and serum biochemical values in cynomolgus monkeys (Macaca fascicularis) bred and reared using the indoor individually-caged system].

Blood samples were collected from 1000 or more apparently healthy cynomolgus monkeys of different ages. All the monkeys had been bred and reared under uniform environmental conditions at the Tsukuba Primate Center for Medical Science, NIH, Japan. Biochemical and hematological data were determined with these samples. The calculated arithmetic means and standard deviations were listed for each item of measurement performed (Tables 3, 4 and 5). The correlation between the obtained value and the age was analyzed using a statistical significance level of 0.1% (Table 6). It was revealed that hemoglobin concentration, mean corpuscular volume, alubuminglobulin ratio and triglyceride concentration increased with age, whereas red blood cell count and serum alkaline phosphatase activity decreased with age in both sexes.