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SMOC2 promoted vascular smooth muscle cell proliferation, migration, and extracellular matrix degradation by activating BMP/TGF-β1 signaling pathway.

作者信息

Wang Xiaowei, Wang Meng, Zhou Zhongxiao, Zou Xin, Song Guoxin, Zhang Qingsong, Zhou Haimeng

机构信息

Department of Vascular Surgery, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, No. 70 Heping Road, Huancui District, Weihai, Shandong 264200, China.

Department of Nephrology, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, No. 70 Heping Road, Huancui District, Weihai, Shandong 264200, China.

出版信息

J Clin Biochem Nutr. 2023 Sep;73(2):116-123. doi: 10.3164/jcbn.22-100. Epub 2023 Jul 5.

DOI:10.3164/jcbn.22-100
PMID:37700850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10493216/
Abstract

A widespread degenerative condition of the aorta, abdominal aortic aneurysm (AAA), severely endangers the health of middle-aged and elderly people. SPARC related modular calcium binding2 (SMOC2) is upregulated in the carotid arteries of rats with atherosclerotic lesions, but its function in AAA is still unknown. Therefore, the aim of this research was to evaluate the function of SMOC2 in AAA. The results showed that in the AAA tissues, SMOC2 expression was upregulated compared with healthy controls. Overexpression of SMOC2 promoted vascular smooth muscle cells (VSMCs) proliferation, migration, and extracellular matrix (ECM) degradation. In contrast, silence of SMOC2 inhibited VSMCs proliferation, migration, and ECM degradation. Overexpression of SMOC2 promoted BMP and TGF-β1 expression and silence of SMOC2 had an opposite effect. Besides, inhibition of BMP or TGF-β1 suppressed VSMCs cell proliferation, migration, and ECM degradation. Moreover, inhibition BMP or TGF-β1 reversed the promotive effects of SMOC2 overexpression on VSMCs proliferation, migration, and ECM degradation. SMOC2 may affecte the formation of AAA by upregulating BMP and TGF-β1 to regulate the proliferation, migration, and ECM degradation of VSMCs.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de6/10493216/effa019319b1/jcbn22-100f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de6/10493216/115bfd03de87/jcbn22-100f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de6/10493216/3caad4651a24/jcbn22-100f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de6/10493216/bca010f4ed8c/jcbn22-100f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de6/10493216/dd5a4d79d2b2/jcbn22-100f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de6/10493216/effa019319b1/jcbn22-100f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de6/10493216/115bfd03de87/jcbn22-100f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de6/10493216/3caad4651a24/jcbn22-100f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de6/10493216/bca010f4ed8c/jcbn22-100f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de6/10493216/dd5a4d79d2b2/jcbn22-100f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de6/10493216/effa019319b1/jcbn22-100f05.jpg

相似文献

[1]
SMOC2 promoted vascular smooth muscle cell proliferation, migration, and extracellular matrix degradation by activating BMP/TGF-β1 signaling pathway.

J Clin Biochem Nutr. 2023-9

[2]
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[3]
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[4]
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J Cell Biochem. 2018-10-9

[5]
[Roles of periostin in proliferation and migration of vascular smooth muscle cells and the effect of atorvastatin on them].

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[6]
Suppression of SMOC2 reduces bleomycin (BLM)-induced pulmonary fibrosis by inhibition of TGF-β1/SMADs pathway.

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[7]
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Ann Vasc Surg. 2017-7

[8]
SMOC2 plays a role in heart failure via regulating TGF-β1/Smad3 pathway-mediated autophagy.

Open Med (Wars). 2023-7-11

[9]
Secreted modular calcium-binding protein 2 promotes high fat diet (HFD)-induced hepatic steatosis through enhancing lipid deposition, fibrosis and inflammation via targeting TGF-β1.

Biochem Biophys Res Commun. 2018-12-20

[10]
Circular RNA RBM33 contributes to extracellular matrix degradation miR-4268/EPHB2 axis in abdominal aortic aneurysm.

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引用本文的文献

[1]
Proteome-Wide Mendelian Randomization Identifies Natriuretic Peptide-B and Novel Proteins as Potential Regulators of Pulse Pressure in Humans.

J Am Heart Assoc. 2025-8-19

[2]
The Pathophysiological Role of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm.

Cells. 2025-7-2

[3]
SMOC2, OGN, FCN3, and SERPINA3 could be biomarkers for the evaluation of acute decompensated heart failure caused by venous congestion.

Front Cardiovasc Med. 2024-12-9

[4]
Identification of distinct and shared biomarker panels in different manifestations of cerebral small vessel disease through proteomic profiling.

medRxiv. 2024-6-10

[5]
FTO Positively Regulates Odontoblastic Differentiation via SMOC2 in Human Stem Cells from the Apical Papilla under Inflammatory Microenvironment.

Int J Mol Sci. 2024-4-5

本文引用的文献

[1]
Lysozyme Improves the Inhibitory Effects of Saponins on Phenotype Transformation of Vascular Smooth Muscle Cells by Binding to Ginsenoside Re.

Front Nutr. 2021-12-23

[2]
A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects.

Bone. 2021-1

[3]
Gadd153 deficiency attenuates abdominal aortic aneurysm formation in mice.

Int J Clin Exp Pathol. 2018-1-1

[4]
Cortistatin exerts antiproliferation and antimigration effects in vascular smooth muscle cells stimulated by Ang II through suppressing ERK1/2, p38 MAPK, JNK and ERK5 signaling pathways.

Ann Transl Med. 2019-10

[5]
Matrix Metalloproteinase in Abdominal Aortic Aneurysm and Aortic Dissection.

Pharmaceuticals (Basel). 2019-8-6

[6]
Long non-coding RNA HIF1A-AS1 is upregulated in intracranial aneurysms and participates in the regulation of proliferation of vascular smooth muscle cells by upregulating TGF-β1.

Exp Ther Med. 2019-3

[7]
Expression of a Novel Long Noncoding RNA (lncRNA), GASL1, is Downregulated in Patients with Intracranial Aneurysms and Regulates the Proliferation of Vascular Smooth Muscle Cells In Vitro.

Med Sci Monit. 2019-2-11

[8]
Secreted modular calcium-binding protein 2 promotes high fat diet (HFD)-induced hepatic steatosis through enhancing lipid deposition, fibrosis and inflammation via targeting TGF-β1.

Biochem Biophys Res Commun. 2018-12-20

[9]
Upregulation of lincRNA-p21 in thoracic aortic aneurysms is involved in the regulation of proliferation and apoptosis of vascular smooth muscle cells by activating TGF-β1 signaling pathway.

J Cell Biochem. 2018-10-9

[10]
SMOC2 inhibits calcification of osteoprogenitor and endothelial cells.

PLoS One. 2018-6-13

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