Dolkar Tsering, Rayapureddy Aditya Keerthi, Kadakia Nevil, Bellamkonda Amulya, Kalavar Madhumati
Internal Medicine, One Brooklyn Health (OBH) Interfaith Medical Center, New York City, USA.
Hematology and Oncology, One Brooklyn Health (OBH) Interfaith Medical Center, New York City, USA.
Cureus. 2023 Aug 12;15(8):e43368. doi: 10.7759/cureus.43368. eCollection 2023 Aug.
Ovarian cancer is among the most common types of cancer suffered by the female population. As of United States Cancer Statistics (USCS) 2019, the National Cancer Institute reports the prevalence of ovarian cancer as 11.4 cases per every 100,000 each year. The highest prevalence is in the seventh decade of life. Of all the types, sex cord-stromal tumors (SCSTs) account for 5-8% of cases. They are a heterogeneous group of rare neoplasms originating from the ovarian matrix, and nearly 90% of the hormone-producing tumors are SCSTs. Hence, patients with SCSTs are known to present with excess estrogen and androgen signs and symptoms. Many SCSTs are known for their indolent course and tendency to affect the unilateral ovary. The prognosis of the malignancy depends on the subtype of SCST, the stage of the patient's disease, and age. Among all the types, 20-50% of the ovaries' granulosa cell tumors tend to recur decades after the initial presentation, and 70% of the recurrences end up with a very poor prognosis. This case will discuss a 68-year-old woman who presented with a recurrence of an adult granulosa cell tumor after 13 years in remission. The patient had been previously diagnosed with an adult granulosa cell tumor of the right ovary at age 55 and had undergone surgical resection along with chemotherapy.
卵巢癌是女性群体中最常见的癌症类型之一。根据美国癌症统计数据（USCS）2019年的报告，美国国立癌症研究所称卵巢癌的发病率为每年每10万人中有11.4例。发病率最高的年龄段是70岁左右。在所有类型中，性索间质肿瘤（SCST）占病例的5 - 8%。它们是一组异质性的罕见肿瘤，起源于卵巢基质，近90%的产生激素的肿瘤是SCST。因此，已知患有SCST的患者会出现雌激素和雄激素过多的体征和症状。许多SCST以其惰性病程和倾向于累及单侧卵巢而闻名。恶性肿瘤的预后取决于SCST的亚型、患者疾病的分期和年龄。在所有类型中，20 - 50%的卵巢颗粒细胞瘤在初次发病数十年后有复发倾向，70%的复发最终预后很差。本病例将讨论一名68岁女性，她在缓解13年后出现成人颗粒细胞瘤复发。该患者曾在55岁时被诊断为右侧卵巢成人颗粒细胞瘤，并接受了手术切除及化疗。
