Garg Monal, Ahlawat Ritu, Mathew Jimmy, Bhati Priya, Thomas Sam, Samuel Sanju
Gynecologic Oncology, Amrita Institute of Medical Sciences, Kochi, IND.
Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, IND.
Cureus. 2024 Nov 28;16(11):e74708. doi: 10.7759/cureus.74708. eCollection 2024 Nov.
A 50-year-old woman with a history of adult granulosa cell tumor (AGCT) of the right ovary was under follow-up after undergoing several surgeries, including a total abdominal hysterectomy with bilateral salpingo-oophorectomy. She was initially diagnosed eight years ago and remained disease-free for 52 months. However, she later experienced a recurrence, indicated by elevated inhibin B levels (58 ng/mL) and the presence of peritoneal soft tissue tumors. Following secondary debulking surgery, histopathology confirmed recurrent granulosa cell tumor (GCT). Although she was advised to undergo hormonal therapy, she was lost to follow-up. After 21 months, she returned with an increased inhibin B level of 82 ng/mL, but imaging showed no signs of recurrence. Following a disease-free interval (DFI) of 23 months, an abdominal lump was discovered, prompting tertiary debulking surgery. During this procedure, cystic lesions were excised, and a large defect in the rectus sheath was repaired using a left rectus abdominis flap, followed by the placement of a mesh. Postsurgery, she received adjuvant chemotherapy consisting of paclitaxel and carboplatin. She had a favorable recovery with no complications during the postoperative period. At the six-month follow-up, her wound had healed well, and she was doing well overall. Isolated recurrent AGCT on the abdominal wall is a very rare presentation and can be managed using debulking surgery, with a multidisciplinary team playing a crucial role.
一名50岁女性,有右侧卵巢成人颗粒细胞瘤(AGCT)病史,在接受了包括全腹子宫切除术加双侧输卵管卵巢切除术在内的多次手术后接受随访。她八年前首次被诊断出,并且52个月内无疾病复发。然而,她后来出现复发,表现为抑制素B水平升高(58 ng/mL)以及存在腹膜软组织肿瘤。二次肿瘤细胞减灭术后,组织病理学证实为复发性颗粒细胞瘤(GCT)。尽管建议她接受激素治疗,但她失访了。21个月后,她回来时抑制素B水平升至82 ng/mL,但影像学检查未显示复发迹象。在无病间期(DFI)23个月后,发现腹部有肿块,于是进行了三次肿瘤细胞减灭术。在此手术过程中,切除了囊性病变,并用左腹直肌瓣修复了腹直肌鞘的一个大缺损,随后放置了网片。术后,她接受了由紫杉醇和卡铂组成的辅助化疗。术后她恢复良好,没有并发症。在六个月的随访中,她的伤口愈合良好,总体情况良好。腹壁孤立性复发性AGCT是一种非常罕见的表现,可以通过肿瘤细胞减灭术进行治疗,多学科团队起着关键作用。