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手术历程:一例成人卵巢颗粒细胞瘤罕见孤立性腹壁复发的病例报告

The Surgical Odyssey: A Case Report on Rare Isolated Abdominal Wall Recurrence in an Adult Ovarian Granulosa Cell Tumor.

作者信息

Garg Monal, Ahlawat Ritu, Mathew Jimmy, Bhati Priya, Thomas Sam, Samuel Sanju

机构信息

Gynecologic Oncology, Amrita Institute of Medical Sciences, Kochi, IND.

Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, IND.

出版信息

Cureus. 2024 Nov 28;16(11):e74708. doi: 10.7759/cureus.74708. eCollection 2024 Nov.

DOI:10.7759/cureus.74708
PMID:39735028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11682846/
Abstract

A 50-year-old woman with a history of adult granulosa cell tumor (AGCT) of the right ovary was under follow-up after undergoing several surgeries, including a total abdominal hysterectomy with bilateral salpingo-oophorectomy. She was initially diagnosed eight years ago and remained disease-free for 52 months. However, she later experienced a recurrence, indicated by elevated inhibin B levels (58 ng/mL) and the presence of peritoneal soft tissue tumors. Following secondary debulking surgery, histopathology confirmed recurrent granulosa cell tumor (GCT). Although she was advised to undergo hormonal therapy, she was lost to follow-up. After 21 months, she returned with an increased inhibin B level of 82 ng/mL, but imaging showed no signs of recurrence. Following a disease-free interval (DFI) of 23 months, an abdominal lump was discovered, prompting tertiary debulking surgery. During this procedure, cystic lesions were excised, and a large defect in the rectus sheath was repaired using a left rectus abdominis flap, followed by the placement of a mesh. Postsurgery, she received adjuvant chemotherapy consisting of paclitaxel and carboplatin. She had a favorable recovery with no complications during the postoperative period. At the six-month follow-up, her wound had healed well, and she was doing well overall. Isolated recurrent AGCT on the abdominal wall is a very rare presentation and can be managed using debulking surgery, with a multidisciplinary team playing a crucial role.

摘要

一名50岁女性,有右侧卵巢成人颗粒细胞瘤(AGCT)病史,在接受了包括全腹子宫切除术加双侧输卵管卵巢切除术在内的多次手术后接受随访。她八年前首次被诊断出,并且52个月内无疾病复发。然而,她后来出现复发,表现为抑制素B水平升高(58 ng/mL)以及存在腹膜软组织肿瘤。二次肿瘤细胞减灭术后,组织病理学证实为复发性颗粒细胞瘤(GCT)。尽管建议她接受激素治疗,但她失访了。21个月后,她回来时抑制素B水平升至82 ng/mL,但影像学检查未显示复发迹象。在无病间期(DFI)23个月后,发现腹部有肿块,于是进行了三次肿瘤细胞减灭术。在此手术过程中,切除了囊性病变,并用左腹直肌瓣修复了腹直肌鞘的一个大缺损,随后放置了网片。术后,她接受了由紫杉醇和卡铂组成的辅助化疗。术后她恢复良好,没有并发症。在六个月的随访中,她的伤口愈合良好,总体情况良好。腹壁孤立性复发性AGCT是一种非常罕见的表现,可以通过肿瘤细胞减灭术进行治疗,多学科团队起着关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9d/11682846/c1ba3c3fea64/cureus-0016-00000074708-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9d/11682846/e5308519bde6/cureus-0016-00000074708-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9d/11682846/f412f74d53a6/cureus-0016-00000074708-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9d/11682846/c1ba3c3fea64/cureus-0016-00000074708-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9d/11682846/e5308519bde6/cureus-0016-00000074708-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9d/11682846/f412f74d53a6/cureus-0016-00000074708-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa9d/11682846/c1ba3c3fea64/cureus-0016-00000074708-i03.jpg

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本文引用的文献

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A case of adult granulosa cell tumor presenting as thoracic lesions.一例表现为胸部病变的成人颗粒细胞瘤。
Gen Thorac Cardiovasc Surg Cases. 2023 Apr 21;2(1):14. doi: 10.1186/s44215-023-00038-1.
2
Story of 20 Years of Triumph: A Case Report of Two Patients With Stage IV Granulosa Cell Tumor of the Ovary.二十年的抗癌胜利故事:两例卵巢IV期颗粒细胞瘤患者的病例报告
Cureus. 2024 Apr 4;16(4):e57615. doi: 10.7759/cureus.57615. eCollection 2024 Apr.
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Recurrent Granulosa Cell Tumor in a Postmenopausal Woman: A Case Report and Literature Review.
一名绝经后女性的复发性颗粒细胞瘤:病例报告及文献综述
Cureus. 2023 Aug 12;15(8):e43368. doi: 10.7759/cureus.43368. eCollection 2023 Aug.
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Serum vascular endothelial growth factor associated with the progression of granulosa cell tumor: a report of two cases.血清血管内皮生长因子与颗粒细胞瘤的进展相关:两例报告。
J Ovarian Res. 2023 Jun 14;16(1):112. doi: 10.1186/s13048-023-01197-z.
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Adult-Type Ovarian Granulosa Cell Tumour: Treatment Outcomes From a Single-Institution Experience.成人型卵巢颗粒细胞瘤:单机构经验的治疗结果
Cureus. 2022 Nov 3;14(11):e31045. doi: 10.7759/cureus.31045. eCollection 2022 Nov.
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Adult-type granulosa cell tumor of the ovary.成人型卵巢颗粒细胞瘤
Am J Cancer Res. 2022 Aug 15;12(8):3495-3511. eCollection 2022.
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A case of adult granulosa cell tumor of the ovary with long-term survival after multiple recurrences.一例长期生存的卵巢成人颗粒细胞瘤,多次复发。
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