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度普利尤单抗治疗DOCK8缺陷高IgE综合征伴复发性湿疹性疱疹的特应性皮炎的疗效：一例报告

Efficacy of Dupilumab in Treating Atopic Dermatitis With Recurrent Eczema Herpeticum in a Patient With DOCK8-Deficiency Hyper-IgE Syndrome: A Case Report.

作者信息

Johar Reshale A, Hasanain Afnan, Khouqeer Yousef

机构信息

Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.

Dermatology, King Faisal Specialist Hospital and Research Centre, Jeddah, SAU.

出版信息

Cureus. 2023 Aug 12;15(8):e43360. doi: 10.7759/cureus.43360. eCollection 2023 Aug.

DOI:10.7759/cureus.43360
PMID:37701007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10494277/
Abstract

Dupilumab, a monoclonal antibody targeting interleukin 4 and interleukin 13, was used to successfully induce remission of chronic, disseminated eczema herpeticum in a six-year-old girl who has DOCK8-deficiency hyper-IgE syndrome. The patient was started on 200 mg of dupilumab administered once every four weeks. The patient had achieved complete resolution of all active herpetic lesions by the time her third dose was due. During the course of three months, she had not developed any new lesions, and significant improvement of the patient's skin, scalp, hair restoration, and nails was appreciated.

摘要

度普利尤单抗是一种靶向白细胞介素4和白细胞介素13的单克隆抗体，用于成功诱导一名患有DOCK8缺陷型高IgE综合征的6岁女孩的慢性播散性疱疹样湿疹缓解。患者开始使用度普利尤单抗200毫克，每四周给药一次。在第三次给药时，患者所有活动性疱疹病变已完全消退。在三个月的疗程中，她没有出现任何新的病变，并且患者的皮肤、头皮、头发恢复和指甲都有显著改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/03ca7b21ade3/cureus-0015-00000043360-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/ce85c09391e5/cureus-0015-00000043360-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/e20730408cea/cureus-0015-00000043360-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/da031f662239/cureus-0015-00000043360-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/913afeb4bc1f/cureus-0015-00000043360-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/9e444f34bce8/cureus-0015-00000043360-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/03ca7b21ade3/cureus-0015-00000043360-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/ce85c09391e5/cureus-0015-00000043360-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/e20730408cea/cureus-0015-00000043360-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/da031f662239/cureus-0015-00000043360-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/913afeb4bc1f/cureus-0015-00000043360-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/9e444f34bce8/cureus-0015-00000043360-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36fb/10494277/03ca7b21ade3/cureus-0015-00000043360-i06.jpg

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BMC Neurol. 2021 Jul 23;21(1):288. doi: 10.1186/s12883-021-02324-3.
2
Dupilumab (Dupixent): An Interleukin-4 Receptor Antagonist for Atopic Dermatitis.度普利尤单抗（达必妥）：一种用于特应性皮炎的白细胞介素-4受体拮抗剂。
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Clinical Manifestation of Hyper IgE Syndrome Including Otitis Media.高免疫球蛋白 E 综合征的临床表现包括中耳炎。
Front Immunol. 2025 Jan 28;15:1507494. doi: 10.3389/fimmu.2024.1507494. eCollection 2024.
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Pediatr Dermatol. 2025 Mar-Apr;42(2):376-382. doi: 10.1111/pde.15780. Epub 2024 Oct 18.
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