低频点燃作为癫痫的一种新实验模型。

Low-frequency kindling as a new experimental model of epilepsy.

作者信息

Minabe Y, Tanii Y, Kadono Y, Tsutsumi M, Nakamura I

出版信息

Exp Neurol. 1986 Nov;94(2):317-23. doi: 10.1016/0014-4886(86)90105-6.

Abstract

Ten cats were stimulated twice a day in the lateral amygdala with low-frequency stimulation of about 3 Hz until generalized convulsion occurred. After the completion of kindling, the longest interpulse interval required for provocation of generalized convulsion (pulse-interval threshold) was determined in each subject. The pulse-interval threshold was 1300 ms in five cats, and 900 ms in five other cats. Then the stability of pulse-interval threshold and of the number of stimulating pulses required for provocation of afterdischarge when the stimulation was delivered with the pulse-interval threshold (pulse-number threshold) was tested. The pulse-interval threshold, pulse-number threshold, and duration of afterdischarge in each stimulation did not change statistically at the interstimulation interval from 24 h to 7 days. Phenobarbital and diphenylhydantoin elevated the pulse-number threshold significantly. We propose that low-frequency kindling is a valuable experimental model of epilepsy in assessing simply and precisely the susceptibility of the epileptic focus itself and the severity of epileptic seizures.

摘要

对10只猫的杏仁核外侧进行每日两次的低频刺激，频率约为3Hz，直至出现全身性惊厥。点燃完成后，测定每只猫诱发全身性惊厥所需的最长脉冲间隔（脉冲间隔阈值）。5只猫的脉冲间隔阈值为1300毫秒，另外5只猫为900毫秒。然后测试当以脉冲间隔阈值（脉冲数阈值）进行刺激时，脉冲间隔阈值以及诱发后放电所需刺激脉冲数的稳定性。在24小时至7天的刺激间隔期内，每次刺激的脉冲间隔阈值、脉冲数阈值和后放电持续时间在统计学上均无变化。苯巴比妥和苯妥英显著提高了脉冲数阈值。我们认为低频点燃是一种有价值的癫痫实验模型，可用于简单而精确地评估癫痫病灶本身的易感性和癫痫发作的严重程度。