Soleimani Damaneh Mohadeseh, Fatahi Somaye, Aryaeian Naheed, Bavi Behbahani Hossein
Department of Nutrition, School of Public Health Iran University of Medical Sciences Tehran Iran.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran.
Food Sci Nutr. 2023 Jun 7;11(9):4912-4925. doi: 10.1002/fsn3.3478. eCollection 2023 Sep.
Coenzyme Q10 is a potent antioxidant and is necessary for energy production in mitochondria. Clinical data have suggested that coenzyme Q10 (CoQ10) has some beneficial effects on liver function. However, these results are equivocal. This systematic review and meta-analysis aimed to clarify the effect of coenzyme Q10 supplementation on the serum concentration of liver function enzymes. We searched the online databases using relevant keywords up to April 2022. Randomized clinical trials (RCTs) investigating the effect of CoQ10, compared with a control group, on serum concentrations of liver enzymes were included. We found a significant reduction following supplementation with CoQ10 on serum concentrations of alanine aminotransferase (ALT) based on 15 effect sizes from 13 RCTs (weighted mean difference [WMD] = -5.33 IU/L; 95% CI: -10.63, -0.03; = .04), aspartate aminotransferase (AST) based on 15 effect sizes from 13 RCTs (WMD = -4.91 IU/L; 95% CI: -9.35, -0.47; = .03) and gamma-glutamyl transferase (GGT) based on eight effect sizes from six RCTs (WMD = -8.07 IU/L; 95% CI: -12.82, -3.32; = .001; = 91.6%). However, we found no significant effects of CoQ10 supplementation on alkaline phosphatase concentration (WMD = 1.10 IU/L; 95% CI: -5.98, 8.18; = .76). CoQ10 supplementation significantly improves circulating ALT, AST, and GGT levels; therefore, it might positively affect liver function. Further high-quality RCTs with more extended intervention periods and larger sample sizes are recommended to confirm our results.
辅酶Q10是一种强效抗氧化剂，是线粒体能量产生所必需的。临床数据表明，辅酶Q10（CoQ10）对肝功能有一些有益作用。然而，这些结果并不明确。本系统评价和荟萃分析旨在阐明补充辅酶Q10对肝功能酶血清浓度的影响。我们使用相关关键词检索了截至2022年4月的在线数据库。纳入了与对照组相比，研究CoQ10对肝酶血清浓度影响的随机临床试验（RCT）。基于13项RCT的15个效应量，我们发现补充CoQ10后，血清丙氨酸氨基转移酶（ALT）浓度显著降低（加权平均差[WMD]=-5.33IU/L；95%置信区间：-10.63，-0.03；P=.04）；基于13项RCT的15个效应量，天冬氨酸氨基转移酶（AST）浓度显著降低（WMD=-4.91IU/L；95%置信区间：-9.35，-0.47；P=.03）；基于6项RCT的8个效应量，γ-谷氨酰转移酶（GGT）浓度显著降低（WMD=-8.07IU/L；95%置信区间：-12.82，-3.32；P=.001；I²=91.6%）。然而，我们发现补充CoQ10对碱性磷酸酶浓度没有显著影响（WMD=1.10IU/L；95%置信区间：-5.98，8.18；P=.76）。补充CoQ10可显著改善循环中ALT、AST和GGT水平；因此，它可能对肝功能产生积极影响。建议进一步开展高质量、干预期更长、样本量更大的RCT以证实我们的结果。
