Jafari Ali
Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran.
Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN) Tehran Iran.
Health Sci Rep. 2025 Feb 10;8(2):e70452. doi: 10.1002/hsr2.70452. eCollection 2025 Feb.
Cardiovascular diseases (CVDs), encompassing a variety of conditions affecting the heart and blood vessels, remain a significant global public health challenge. Among various therapeutic options, Coenzyme Q10 (CoQ10) has garnered attention due to its potential benefits for cardiovascular health. CoQ10 is a naturally occurring antioxidant that plays a crucial role in cellular energy production and has long been used therapeutically. This study aims to summarize and systematically analyze the scientific literature on glycemic profile, lipid profile, anthropometric measures, blood pressure, inflammatory factors, liver function tests, oxidative stress parameters and adipokines associated with CoQ10 supplementation to provide a basis for clinical treatment.
A systematic electronic search will be conducted to identify articles published from inception to July 2024 across databases including PubMed, Scopus, Web of Science, CENTRAL, and EMBASE. The search will focus on randomized controlled trials (RCTs) involving both healthy and unhealthy participants. Two independent reviewers will evaluate articles, extract data, and assess study quality using the Cochrane risk of bias tool. Discrepancies will be resolved through consultation with a third reviewer. If a sufficient number of eligible studies are identified, a meta-analysis will be performed on the selected outcomes.
The results will provide a comprehensive synthesis of the effects of CoQ10 supplementation on cardiovascular disease risk factors, including glycemic profile, lipid profile, anthropometric measures, blood pressure, inflammatory factors, liver function tests, oxidative stress parameters, and adipokines.
This protocol outlines a comprehensive approach to systematically review and perform a dose-response meta-analysis on the effects of CoQ10 supplementation on CVD risk factors. The study will employ rigorous methodologies, including independent evaluation and GRADE assessment, to ensure high-quality evidence synthesis from RCTs.
心血管疾病（CVDs）涵盖影响心脏和血管的多种病症，仍然是一项重大的全球公共卫生挑战。在各种治疗选择中，辅酶Q10（CoQ10）因其对心血管健康的潜在益处而受到关注。CoQ10是一种天然存在的抗氧化剂，在细胞能量产生中起关键作用，长期以来一直用于治疗。本研究旨在总结并系统分析关于补充CoQ10与血糖谱、血脂谱、人体测量指标、血压、炎症因子、肝功能检查、氧化应激参数和脂肪因子相关的科学文献，为临床治疗提供依据。
将进行系统的电子检索，以识别从数据库创建至2024年7月发表的文章，这些数据库包括PubMed、Scopus、科学网、Cochrane系统评价数据库和EMBASE。检索将聚焦于涉及健康和不健康参与者的随机对照试验（RCTs）。两名独立的评审人员将评估文章、提取数据，并使用Cochrane偏倚风险工具评估研究质量。分歧将通过与第三位评审人员协商解决。如果确定有足够数量的符合条件的研究，将对选定的结果进行荟萃分析。
结果将全面综合补充CoQ10对心血管疾病危险因素的影响，包括血糖谱、血脂谱、人体测量指标、血压、炎症因子、肝功能检查、氧化应激参数和脂肪因子。
本方案概述了一种全面的方法，用于系统评价并对补充CoQ10对CVD危险因素的影响进行剂量反应荟萃分析。该研究将采用严格的方法，包括独立评估和GRADE评估，以确保从RCTs中合成高质量的证据。
