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Immunoquantitation of some cytochrome P-450 isozymes in liver microsomes from streptozotocin-diabetic rats.

作者信息

Rouer E, Beaune P, Leroux J P

出版信息

Experientia. 1986 Oct 15;42(10):1162-3. doi: 10.1007/BF01941293.

DOI:10.1007/BF01941293
PMID:3770136
Abstract

Streptozotocin-diabetes in rats leads to a decrease of cytochrome P-450 UT-A (the major form in control rats) and an increase of cytochrome P-450 PB-B (the major one induced by phenobarbital treatment) in liver microsomes. The increased benzphetamine-N-demethylase activity can be related to the induction of cytochrome P-450 PB-B.

摘要

相似文献

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Immunoquantitation of some cytochrome P-450 isozymes in liver microsomes from streptozotocin-diabetic rats.
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2
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本文引用的文献

1
The metabolism of drugs by liver microsomes from alloxan-diabetic rats.四氧嘧啶糖尿病大鼠肝脏微粒体对药物的代谢作用
J Pharmacol Exp Ther. 1961 Jul;133:7-11.
2
Effect of diabetes on rat liver cytochrome P-450. Evidence for a unique diabetes-dependent rat liver cytochrome P-450.糖尿病对大鼠肝脏细胞色素P-450的影响。一种独特的依赖糖尿病的大鼠肝脏细胞色素P-450的证据。
Biochem Pharmacol. 1982 Oct 15;31(20):3329-34. doi: 10.1016/0006-2952(82)90569-x.
3
Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
采用免疫化学染色结合十二烷基硫酸钠-聚丙烯酰胺凝胶电泳法对大鼠、兔子和人类微粒体细胞色素P-450同工酶进行测定。
Biochemistry. 1982 Mar 30;21(7):1698-706. doi: 10.1021/bi00536a035.
4
A cytochrome P-450 multigene family. Characterization of a gene activated by phenobarbital administration.一个细胞色素P - 450多基因家族。苯巴比妥给药激活的一个基因的特性。
J Biol Chem. 1983 Sep 25;258(18):11285-95.
5
Immunochemical characterization of some monooxygenase activities in liver microsomes from untreated and phenobarbital-treated rats.未处理和苯巴比妥处理大鼠肝脏微粒体中某些单加氧酶活性的免疫化学特性分析
Biochem Biophys Res Commun. 1981 Jul 30;101(2):547-54. doi: 10.1016/0006-291x(81)91294-8.
6
Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone.肝脏微粒体细胞色素P-450的纯化与特性：从经苯巴比妥或β-萘黄酮处理的大鼠中分离出的8种同工酶的电泳、光谱、催化和免疫化学性质及诱导性
Biochemistry. 1982 Nov 9;21(23):6019-30. doi: 10.1021/bi00266a045.
7
Differential effects of diabetes on microsomal metabolism of various substrates. Comparison of streptozotocin and spontaneously diabetic Wistar rats.
Biochem Pharmacol. 1983 Jan 15;32(2):327-35. doi: 10.1016/0006-2952(83)90563-4.
8
Study of benzphetamine-N-demethylase in streptozotocin-diabetic mice and rats: evidence for the induction of catalytically and immunologically specific forms of cytochrome P450.链脲佐菌素诱导的糖尿病小鼠和大鼠中苄非他明-N-脱甲基酶的研究：细胞色素P450催化和免疫特异性形式诱导的证据
Biochimie. 1983 Nov-Dec;65(11-12):679-83. doi: 10.1016/s0300-9084(84)80032-2.
9
Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution.细胞色素P-450的多种形式以及分子生物学和进化的重要性。
Biochem Pharmacol. 1982 Jul 15;31(14):2311-7. doi: 10.1016/0006-2952(82)90523-8.
10
Sex differences in the effects of abnormal physiological states on the metabolism of drugs by rat liver microsomes.
J Pharmacol Exp Ther. 1965 Nov;150(2):285-91.