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用于增强癌症免疫治疗的多功能纳米复合材料对肿瘤微环境的调控

Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy.

作者信息

Sharma Prashant, Otto Mario

机构信息

Department of Child Health, University of Arizona College of Medicine-Phoenix, ABC1 Building, 425 N 5th Street, Phoenix, AZ, 85004, USA.

Center for Cancer and Blood Disorders (CCBD), Phoenix Children's, 1919 E Thomas Rd, Phoenix, AZ, 85016, USA.

出版信息

Bioact Mater. 2023 Sep 6;31:440-462. doi: 10.1016/j.bioactmat.2023.08.022. eCollection 2024 Jan.

DOI:10.1016/j.bioactmat.2023.08.022
PMID:37701452
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10494322/
Abstract

Cancer immunotherapy has gained momentum for treating malignant tumors over the past decade. Checkpoint blockade and chimeric antigen receptor cell therapy (CAR-T) have shown considerable potency against liquid and solid cancers. However, the tumor microenvironment (TME) is highly immunosuppressive and hampers the effect of currently available cancer immunotherapies on overall treatment outcomes. Advancements in the design and engineering of nanomaterials have opened new avenues to modulate the TME. Progress in the current nanocomposite technology can overcome immunosuppression and trigger robust immunotherapeutic responses by integrating synergistic functions of different molecules. We will review recent advancements in nanomedical applications and discuss specifically designed nanocomposites modulating the TME for cancer immunotherapy. In addition, we provide information on the current landscape of clinical-stage nanocomposites for cancer immunotherapy.

摘要

在过去十年中，癌症免疫疗法在治疗恶性肿瘤方面获得了发展动力。检查点阻断和嵌合抗原受体细胞疗法（CAR-T）已显示出对液体和实体癌症具有相当大的效力。然而，肿瘤微环境（TME）具有高度免疫抑制性，会阻碍当前可用的癌症免疫疗法对整体治疗效果的影响。纳米材料设计与工程方面的进展为调节肿瘤微环境开辟了新途径。当前纳米复合技术的进步能够通过整合不同分子的协同功能来克服免疫抑制并引发强大的免疫治疗反应。我们将回顾纳米医学应用的最新进展，并特别讨论为癌症免疫疗法调节肿瘤微环境而专门设计的纳米复合材料。此外，我们还提供了用于癌症免疫疗法的临床阶段纳米复合材料的当前情况信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/fd9aba27d610/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/8163fbdaa219/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/0d146fe3d640/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/3efae387f2b7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/2961a2ed1cc4/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/27723e47f3af/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/b8851ffeeed4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/f7c897302a69/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/fd9aba27d610/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/8163fbdaa219/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/0d146fe3d640/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/3efae387f2b7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/2961a2ed1cc4/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/27723e47f3af/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/b8851ffeeed4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/f7c897302a69/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78b9/10494322/fd9aba27d610/gr7.jpg

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[7]
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[9]
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[10]
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本文引用的文献

[1]
Nano-vaccines combining customized in situ anti-PD-L1 depot for enhanced tumor immunotherapy.

Nanomedicine. 2023-9

[2]
Microfluidics-Enabled Nanovesicle Delivers CD47/PD-L1 Antibodies to Enhance Antitumor Immunity and Reduce Immunotoxicity in Lung Adenocarcinoma.

Adv Sci (Weinh). 2023-7

[3]
Surface-Engineered Monocyte Immunotherapy Combined Graphene Quantum Dots Effective Against Solid Tumor Targets.

Int J Nanomedicine. 2023

[4]
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Bioact Mater. 2022-7-17

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Triple-Combination Immunogenic Nanovesicles Reshape the Tumor Microenvironment to Potentiate Chemo-Immunotherapy in Preclinical Cancer Models.

Adv Sci (Weinh). 2023-5

[6]
Tumor Cell-Derived Microparticles Induced by Methotrexate Augment T-cell Antitumor Responses by Downregulating Expression of PD-1 in Neutrophils.

Cancer Immunol Res. 2023-4-3

[7]
A nanoadjuvant that dynamically coordinates innate immune stimuli activation enhances cancer immunotherapy and reduces immune cell exhaustion.

Nat Nanotechnol. 2023-4

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Polymeric microneedles enable simultaneous delivery of cancer immunomodulatory drugs and detection of skin biomarkers.

Theranostics. 2023

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Combination of genetically engineered T cells and immune checkpoint blockade for the treatment of cancer.

Immunother Adv. 2022-1-25

[10]
Nanotechnology-Based siRNA Delivery Systems to Overcome Tumor Immune Evasion in Cancer Immunotherapy.

Pharmaceutics. 2022-6-25

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