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蝉蜕改善特应性皮炎中的苔藓化，通过抑制白细胞介素（IL）-22/Janus激酶（JAK）1/信号转导及转录激活因子（STAT）3通路。

The Slough of Cicadidae Periostracum Ameliorated Lichenification by Inhibiting Interleukin (IL)-22/Janus Kinase (JAK) 1/Signal Transducer and Activator of Transcription (STAT) 3 Pathway in Atopic Dermatitis.

作者信息

Park Ganghye, Kwon Namgyu, Kim Mi Hye, Yang Woong Mo

机构信息

Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.

出版信息

Food Sci Anim Resour. 2023 Sep;43(5):859-876. doi: 10.5851/kosfa.2023.e40. Epub 2023 Sep 1.

DOI:10.5851/kosfa.2023.e40
PMID:37701738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10493567/
Abstract

It is known that animal-origin medicine could be one of effective treatment to remedy atopic dermatitis (AD) by controlling the cytokines. Cicadidae Periostracum (CP), the slough of , has been frequently used for treating AD and skin affliction in traditional Korean Medicine. This study is aimed at investigating the ameliorating effects of CP on AD and its potential mechanism. The dinitrochlorobenzene sensitized mice were treated with CP for 2 weeks. The various biomarkers and the dermatitis scores presented that CP treatment can induce the visual and biological improvements of AD model. Pruritus, the most serious symptom of AD, which can cause repeated scratching behaviors and finally lead to lichenification, was reduced with CP treatment by regulating the inflammatory reactions. In addition, CP treatment diminished the number of mast cells that are known for causing inflammatory reactions. Moreover, it is proven that CP can decline secretion of interleukin-22, which means CP treatment has anti-inflammatory effects. CP treatment can correct the imbalance of helper T (Th)1 and Th2, downregulating thymic stromal lymphopoietin that leads to decrease of mRNA level of inflammatory cytokines. The crucial role of CP treatment is controlling of the Janus kinase 1/signal transducer and activator of transcription 3 pathway. In addition, CP treatment has the inhibitory effects on kallikrein related peptidase (KLK) 5 and KLK7. Taken together, CP treatment can ameliorate most symptoms and problems caused by AD disease, improving the AD patients' life quality.

摘要

众所周知，动物源药物可通过控制细胞因子成为治疗特应性皮炎（AD）的有效方法之一。蝉蜕（CP），即蝉的蜕皮，在传统韩医学中常用于治疗AD和皮肤疾病。本研究旨在探讨CP对AD的改善作用及其潜在机制。用CP处理二硝基氯苯致敏的小鼠2周。各种生物标志物和皮炎评分表明，CP治疗可使AD模型在视觉和生物学上得到改善。AD最严重的症状瘙痒可导致反复搔抓行为并最终导致苔藓化，CP治疗通过调节炎症反应减轻了瘙痒。此外，CP治疗减少了已知会引起炎症反应的肥大细胞数量。而且，已证明CP可降低白细胞介素-22的分泌，这意味着CP治疗具有抗炎作用。CP治疗可纠正辅助性T（Th）1和Th2的失衡，下调胸腺基质淋巴细胞生成素，从而导致炎症细胞因子mRNA水平降低。CP治疗的关键作用是控制Janus激酶1/信号转导子和转录激活子3途径。此外，CP治疗对激肽释放酶相关肽酶（KLK）5和KLK7有抑制作用。综上所述，CP治疗可改善AD疾病引起的大多数症状和问题，提高AD患者的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/5e03e35d2ada/kosfa-43-5-859-g9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/6afa60308f22/kosfa-43-5-859-g1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/bb3c3cce64af/kosfa-43-5-859-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/dd5ba2080bf5/kosfa-43-5-859-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/54ae64e69ab0/kosfa-43-5-859-g8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/5e03e35d2ada/kosfa-43-5-859-g9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/6afa60308f22/kosfa-43-5-859-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/479c1a67a27e/kosfa-43-5-859-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/d9a0f5f8016f/kosfa-43-5-859-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/3b97ac6d5695/kosfa-43-5-859-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/8bc53705a23c/kosfa-43-5-859-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/bb3c3cce64af/kosfa-43-5-859-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/dd5ba2080bf5/kosfa-43-5-859-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/54ae64e69ab0/kosfa-43-5-859-g8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2710/10493567/5e03e35d2ada/kosfa-43-5-859-g9.jpg

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