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水提取物的脱落皮肤对辐射诱导的睾丸损伤小鼠模型的保护作用

Protective Effect of Cast-Off Skin of Water Extract in a Radiation-Induced Testicular Injury Mice Model.

作者信息

Seo Yun-Soo, Ryu Seung Mok, Lee Jun, Jeong Huiyeong, Choi Goya, Moon Byeong Cheol, Lim Je-Oh, Nam Hyeon-Hwa, Kim Joong-Sun, Lee Sueun

机构信息

Herbal Medicine Resources Research Center Korea Institute of Oriental Medicine Naju Republic of Korea.

College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University Gwangju Republic of Korea.

出版信息

Food Sci Nutr. 2025 Apr 24;13(4):e70198. doi: 10.1002/fsn3.70198. eCollection 2025 Apr.

DOI:10.1002/fsn3.70198
PMID:40291930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12021667/
Abstract

Radiation therapy has been used to treat cancer; however, the associated DNA damage and adverse effects in the surrounding tissues remain major concerns. In radiation injury, several natural remedies can effectively relieve symptoms with minimal side effects. (CP, also called "Sun-Tae") is the cast-off shell of Fabricius and has been traditionally used for several pharmacological actions. This study investigated the protective effects of CP water extract (CPE) on irradiated testicular tissue and spermatogenesis. The chemical constituents of CPE were analyzed using a high-performance liquid chromatography system equipped with a mass detector and were determined to be dimeric -acetyl dopamine derivatives. The testes and epididymal tissues of male C57BL/6 mice orally pretreated with CPE (25 and 50 mg/kg) 24 h and 15 min before radiation exposure (5 Gy) were collected for analysis. CPE pretreatment ameliorated radiation-induced apoptosis in the testes and inhibited weight loss in the epididymis compared to those of the irradiated group. Treatment with high-dose CPE prevented the radiation-induced decrease in the epithelial height of seminiferous tubules. In addition, the morphology, motility, and number of damaged sperm cells following radiation exposure were alleviated by CPE treatment. Furthermore, the dose-dependent antioxidative activity of CPE was confirmed in 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging assays, and reactive oxygen species generation by hydrogen peroxide was reduced by CPE treatment in vitro. Our findings suggest that pretreatment with CPE can ameliorate testicular tissue damage and sperm degeneration via the antioxidative properties of CPE in radiation-injured testis tissue.

摘要

放射疗法已被用于治疗癌症；然而，相关的DNA损伤以及对周围组织的不良影响仍然是主要问题。在辐射损伤中，几种天然疗法可以有效缓解症状且副作用最小。蝉蜕（CP，也称为“蝉衣”）是蚱蝉的蜕壳，传统上用于多种药理作用。本研究调查了CP水提取物（CPE）对受辐射睾丸组织和精子发生的保护作用。使用配备质量检测器的高效液相色谱系统分析了CPE的化学成分，确定其为二聚体 - 乙酰多巴胺衍生物。在辐射暴露（5 Gy）前24小时和15分钟口服给予CPE（25和50 mg/kg）预处理的雄性C57BL/6小鼠的睾丸和附睾组织被收集用于分析。与辐射组相比，CPE预处理改善了辐射诱导的睾丸细胞凋亡，并抑制了附睾重量减轻。高剂量CPE治疗可防止辐射诱导的生精小管上皮高度降低。此外，CPE治疗减轻了辐射暴露后受损精子细胞的形态、活力和数量。此外，在2,2-二苯基-1-苦基肼和2,2'-偶氮双-(3-乙基苯并噻唑啉-6-磺酸)自由基清除试验中证实了CPE的剂量依赖性抗氧化活性，并且在体外CPE处理减少了过氧化氢产生的活性氧。我们的研究结果表明，CPE预处理可以通过其在辐射损伤睾丸组织中的抗氧化特性改善睾丸组织损伤和精子退化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b1/12021667/67f228d592d0/FSN3-13-e70198-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b1/12021667/6652d0c06705/FSN3-13-e70198-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b1/12021667/83de4ff9cdb2/FSN3-13-e70198-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b1/12021667/96c1a216e564/FSN3-13-e70198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b1/12021667/202a53300c74/FSN3-13-e70198-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b1/12021667/67f228d592d0/FSN3-13-e70198-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b1/12021667/6652d0c06705/FSN3-13-e70198-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b1/12021667/87108d0f67f8/FSN3-13-e70198-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b1/12021667/83de4ff9cdb2/FSN3-13-e70198-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b1/12021667/96c1a216e564/FSN3-13-e70198-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b1/12021667/202a53300c74/FSN3-13-e70198-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16b1/12021667/67f228d592d0/FSN3-13-e70198-g001.jpg

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