Boullie M C, Thomine E, Demenais F, Daveau M, Laurent P
Dermatologica. 1986;173(3):109-15. doi: 10.1159/000249231.
In a family displaying the familial atypical multiple-mole melanoma syndrome, linkage analyses were performed between HLA and an assumed dominant gene respectively determining each of the following affected phenotypes: precursor lesions; cutaneous malignant melanoma (CMM); and precursor lesions or CMM or both. The results suggest that there is a complex mechanism involving several factors, genetic and environmental interacting with the gene determining precursor lesions to cause the neoplastic transformation.
在一个表现出家族性非典型多发性痣黑色素瘤综合征的家族中，分别对HLA与一个假定的显性基因进行了连锁分析，该显性基因分别决定以下每种受影响的表型：前驱病变；皮肤恶性黑色素瘤（CMM）；以及前驱病变或CMM或两者皆有。结果表明，存在一种复杂的机制，涉及几个因素，即遗传因素和环境因素与决定前驱病变的基因相互作用，从而导致肿瘤转化。
