Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Med Oncol. 2023 Sep 13;40(10):297. doi: 10.1007/s12032-023-02155-x.
Malnutrition caused by insufficient nutritional supply may significantly hinder the quality of life among cancer patients. Sugar provides energy and nutritional support, but it also promotes cancer growth. Warburg effect is the reprogrammed glucose metabolic mode of cancer cells that meets the intensified ATP demand and biosynthesis. Vitamin C (VC) has anti-tumor effect. However, the relationship between cytotoxicity of VC on cancer cells and Warburg effect remains elusive, the effect of VC on glucose-induced oncogenic effect is also unclear. Based on colorectal cancer cell HCT116, our finding revealed that the discrepant oncogenic effect of different sugar is closely related to the intensification of Warburg effect, with glucose being the potent oncogenic component. Notably, as a potential Warburg effect inhibitor, VC suppressed cancer growth in a concentration-dependent manner and further reversed the glucose-induced oncogenic effect. Furthermore, VC protected tumor-bearing mice from insulin sensitivity impairment and inflammatory imbalance. These findings imply that VC might be a useful adjuvant treatment for cancer patients seeking to optimize nutritional support.
营养不良是由营养供应不足引起的，可能会显著降低癌症患者的生活质量。糖能提供能量和营养支持，但它也会促进癌症生长。沃伯格效应是癌细胞重新编程的葡萄糖代谢模式，以满足增强的 ATP 需求和生物合成。维生素 C（VC）具有抗肿瘤作用。然而，VC 对癌细胞的细胞毒性与沃伯格效应之间的关系仍不清楚，VC 对葡萄糖诱导的致癌作用的影响也不清楚。基于结直肠癌细胞 HCT116，我们的研究结果表明，不同糖的差异致癌作用与沃伯格效应的强化密切相关，葡萄糖是潜在的致癌成分。值得注意的是，作为一种潜在的沃伯格效应抑制剂，VC 以浓度依赖的方式抑制肿瘤生长，并进一步逆转葡萄糖诱导的致癌作用。此外，VC 还能保护荷瘤小鼠免受胰岛素敏感性受损和炎症失衡的影响。这些发现表明，VC 可能是癌症患者寻求优化营养支持的一种有用的辅助治疗方法。
