Department of Bioengineering, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, 31261, Saudi Arabia; Interdisciplinary Research Center for Hydrogen and Energy Storage (IRC-HES), King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, 31261, Saudi Arabia; Interdisciplinary Research Center for Health & Biosciences, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, 31261, Saudi Arabia.
Mol Aspects Med. 2023 Dec;94:101213. doi: 10.1016/j.mam.2023.101213. Epub 2023 Sep 11.
Most mind boggling diseases are accepted to be impacted by both genetic and environmental elements. As of late, there has been a flood in the improvement of different methodologies, concentrate on plans, and measurable and logical techniques to examine gene-environment cooperations (G × Es) in enormous scope studies including human populaces. The many-sided exchange between genetic elements and environmental openings has long charmed the consideration of clinicians and researchers looking to grasp the complicated starting points of diseases. While single variables can add to disease, the blend of genetic variations and environmental openings frequently decides disease risk. The fundamental point of this paper is to talk about the Gene-Environment Associations That Impact CVD, Lipid Characteristics, Obesity, Diabetes, and Hypertension Have all the earmarks of being Ready to Impact Gene Therapy. This survey paper investigates the meaning of gene-environment collaborations (G × E) in disease advancement. The intricacy of genetic and environmental communications in disease causation is explained, underlining the multifactorial idea of many circumstances. The job of gene-environment cooperations in cardiovascular disease, lipid digestion, diabetes, obesity, and hypertension is investigated. This audit fixates on Gene by Environment (G × E) collaborations, investigating their importance in disease etiology.
大多数令人费解的疾病都被认为受到遗传和环境因素的共同影响。最近,在包括人类群体在内的大规模研究中,各种方法、重点计划、测量和逻辑技术的发展呈爆炸式增长,以研究基因-环境相互作用(G×E)。遗传因素与环境间隙之间的复杂相互作用长期以来一直吸引着临床医生和研究人员的关注,他们希望理解疾病的复杂起源。虽然单个变量可能导致疾病,但遗传变异和环境间隙的组合通常决定了疾病风险。本文的主要目的是讨论影响 CVD、血脂特征、肥胖、糖尿病和高血压的基因-环境关联,似乎都有可能影响基因治疗。本综述论文探讨了基因-环境相互作用(G×E)在疾病发展中的意义。解释了疾病发病机制中遗传和环境通讯的复杂性,强调了许多情况下的多因素概念。研究了基因-环境相互作用在心血管疾病、脂质代谢、糖尿病、肥胖和高血压中的作用。本综述重点关注基因与环境(G×E)的相互作用,探讨它们在疾病病因学中的重要性。