Trimethoprim/sulphamethoxazole and doxycycline in acute exacerbations of chronic bronchitis in general practice: a comparative study.

Fifty-six patients with acute exacerbation of chronic bronchitis were given one week's treatment either with a combination of trimethoprim and sulphamethoxazole (TMP/SMX) or with doxycycline, in a single blind trial. The study found no significant difference in response to the two treatments, and confirmed that both TMP/SMX and doxycycline are effective and well tolerated agents, which are suitable for the management of acute or chronic bronchitis.