Johns Hopkins University, Baltimore, Maryland, USA.
Top Antivir Med. 2023 Jun 30;31(4):538-542.
Comorbid conditions have major impacts on the health, quality of life, and survival of people with HIV, particularly as they age. The 2023 Conference on Retroviruses and Opportunistic Infections (CROI) featured excellent science related to specific comorbidities, such as cardiovascular disease (CVD), cancer, and obesity. Studies investigating factors that may contribute to CVD, such as mental health disorders, antiretroviral therapies, and activation of hormonal pathways, were featured prominently. Other studies sought to understand the epidemiology of non-AIDS-defining cancers in people with HIV. As at previous CROI conferences, weight gain attributable to antiretroviral therapies was a major theme, and several abstracts focused on the important question of whether weight decreases after discontinuation of antiretroviral therapy (ART) regimens associated with weight gain. This review focuses on abstracts presented at CROI 2023 in these areas, highlighting those with the most clinical impact.
合并症对艾滋病毒感染者的健康、生活质量和生存产生重大影响，尤其是随着年龄的增长。2023 年逆转录病毒和机会性感染会议（CROI）展示了与特定合并症相关的优秀科学，如心血管疾病（CVD）、癌症和肥胖。研究调查了可能导致 CVD 的因素，如心理健康障碍、抗逆转录病毒疗法和激素途径的激活，这些因素在会议上得到了突出强调。其他研究旨在了解艾滋病毒感染者中非艾滋病定义性癌症的流行病学。与以往的 CROI 会议一样，抗逆转录病毒疗法引起的体重增加是一个主要主题，有几个摘要重点关注了一个重要问题，即停止与体重增加相关的抗逆转录病毒疗法（ART）方案后体重是否会下降。这篇综述重点介绍了在 CROI 2023 年会议上提交的这些领域的摘要，突出了那些对临床影响最大的摘要。
