CROI 2023：HIV 感染者的神经精神并发症。
CROI 2023: Neuropsychiatric Complications in People With HIV.
机构信息
Emory University, Atlanta, Georgia, USA.
Washington University in St. Louis, Missouri, USA.
出版信息
Top Antivir Med. 2023 Jun 30;31(4):543-555.
The 2023 Conference on Retroviruses and Opportunistic Infections (CROI) featured new and impactful findings about neuropsychiatric complications in people with HIV and other infections. Reports included new evidence of (a) the importance of myeloid cells in the pathogenesis of HIV disease in the central nervous system, including as an HIV reservoir; (b) eukaryotic and prokaryotic viruses in cerebrospinal fluid during suppressive antiretroviral therapy; (c) the influence of sex on pathogenesis, including in novel neuropsychiatric biotypes identified by machine learning and other methods;(d) premature aging in people with HIV, including the brain-age gap observed on magnetic resonance imaging; (e) cellular and soluble biomarkers of neuropsychiatric complications in people with HIV; and (f) the neurotoxicity of certain antiretroviral drugs. This review summarizes these and other new findings and highlights new research directions for the neuro-HIV field.
2023 年逆转录病毒和机会性感染会议（CROI）发布了有关 HIV 感染者和其他感染者神经精神并发症的新的、有影响力的研究结果。报告包括以下新证据：（a）髓样细胞在 HIV 疾病发病机制中的重要性，包括作为 HIV 储库；（b）在抑制性抗逆转录病毒治疗期间脑脊液中的真核和原核病毒；（c）性别对发病机制的影响，包括通过机器学习和其他方法确定的新型神经精神生物型；（d）HIV 感染者的过早衰老，包括在磁共振成像上观察到的大脑年龄差距；（e）HIV 感染者神经精神并发症的细胞和可溶性生物标志物；以及（f）某些抗逆转录病毒药物的神经毒性。本综述总结了这些和其他新发现，并强调了神经 HIV 领域的新研究方向。
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