Ling Cheng, Li Feng, Zhao Jiangyuan, Wen Mengliang, Han Xiulin
National Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University.
Yunnan Provincial Enterprises Key Laboratory for New Drug Creation of Traditional Chinese Medicine and Ethnic Medicine, Yunnan Institute of Materia Medica.
J Oleo Sci. 2023 Oct 3;72(10):889-900. doi: 10.5650/jos.ess23039. Epub 2023 Sep 12.
Nervonic acid (NA) is a very-long-chain monounsaturated fatty acid with great application values. It plays a vital role in the development of brain nervous system and the treatment of neurological diseases, so it has attracted much attention from all walks of life. Although NA has a wide range of sources, its current acquisition methods are still mainly relied on chemical synthesis and plant extraction, which are challenging to meet the market and green industry demands, limiting its development and application. In recent years, with the rapid development of synthetic biology technology, NA biosynthesis has become an alternative production strategy. In this study, we summarize the physicochemical properties, pharmacological activities, resources, biosynthetic pathways and heterologous biosynthesis of NA, and discuss the challenges and prospects of NA biosynthesis. The application prospects of cell-free systems and retrobiosynthesis in NA synthesis were also reviewed.
神经酸（NA）是一种具有重要应用价值的超长链单不饱和脂肪酸。它在大脑神经系统发育和神经疾病治疗中发挥着至关重要的作用，因此受到各界广泛关注。尽管神经酸来源广泛，但其目前的获取方法仍主要依赖化学合成和植物提取，难以满足市场和绿色产业需求，限制了其开发与应用。近年来，随着合成生物学技术的快速发展，神经酸生物合成已成为一种替代性生产策略。在本研究中，我们总结了神经酸的理化性质、药理活性、资源、生物合成途径和异源生物合成，并探讨了神经酸生物合成面临的挑战与前景。还综述了无细胞系统和逆生物合成在神经酸合成中的应用前景。
