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余波未平:挥之不去的 COVID-19 表观遗传学效应。

Over but not gone: lingering epigenetic effects of COVID-19.

机构信息

Program in Cancer and Cell Biology, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX, USA.

Program in Immunology and Microbiology, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX, USA.

出版信息

Trends Immunol. 2023 Oct;44(10):751-753. doi: 10.1016/j.it.2023.08.012. Epub 2023 Sep 11.

Abstract

'Long COVID' affects nearly one in five adults who have had coronavirus disease 2019 (COVID-19), yet the mechanisms underlying this disorder remain poorly understood. In a new study, Cheong et al. show that the epigenetic and transcriptional state of myeloid immune cells and their progenitors are durably altered in patients following severe COVID-19.

摘要

“长新冠”影响了近五分之一曾感染 2019 年冠状病毒病(COVID-19)的成年人,但这种疾病的发病机制仍知之甚少。在一项新的研究中,Cheong 等人表明,在 COVID-19 重症患者中,髓样免疫细胞及其前体细胞的表观遗传和转录状态发生了持久改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a9b/10543559/0bea3d376b7f/nihms-1928888-f0001.jpg

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