Gummere G R, McCormick P J, Bennett D
Genetics. 1986 Sep;114(1):235-45. doi: 10.1093/genetics/114.1.235.
Transmission ratio distortion is a characteristic of complete t-haplotypes, such that heterozygous males preferentially transmit the t-haplotype bearing chromosome 17 to the majority of their progeny. At least two genes contained within the t-haplotype have been identified as being required for such high transmission ratios. In this study we examine the effects of the genetic background and the chromosome homologous to the t-haplotype on transmission ratio distortion. We use two different congenic lines: BTBRTF/Nev.Ttf/t12, in which the t12 haplotype has a transmission ratio of 52%, and C3H/DiSn.Ttf/t12, in which the t12 haplotype has a transmission ratio of 99%. By intercrossing these two strains to produce reciprocal F1 and F2 generations, we have isolated the effects of the homologous chromosome 17 from the effects of the genetic background. We demonstrate that both the homologous chromosome and the genetic background have profound effects on t-haplotype transmission ratio distortion. Furthermore, it is evident that the t-haplotype transmission ratio behaves as a quantitative character rather than an intrinsic property of t-haplotypes.
传递比率畸变是完全t单倍型的一个特征，杂合雄性会优先将携带17号染色体的t单倍型传递给其大多数后代。t单倍型中至少有两个基因已被确定为实现如此高传递比率所必需的。在本研究中，我们研究了遗传背景以及与t单倍型同源的染色体对传递比率畸变的影响。我们使用了两个不同的近交系：BTBRTF/Nev.Ttf/t12，其中t12单倍型的传递比率为52%；以及C3H/DiSn.Ttf/t12，其中t12单倍型的传递比率为99%。通过将这两个品系进行杂交以产生正反交F1和F2代，我们分离出了17号同源染色体的影响与遗传背景的影响。我们证明同源染色体和遗传背景对t单倍型传递比率畸变都有深远影响。此外，很明显t单倍型传递比率表现为一个数量性状，而非t单倍型的固有属性。
