The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, 510182, China.
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA.
Int J Biol Sci. 2023 Aug 21;19(13):4311-4326. doi: 10.7150/ijbs.83531. eCollection 2023.
Gliomas develop in unique and complicated environments that nourish tumor cells. The tumor microenvironment (TME) of gliomas comprises heterogeneous cells, including brain-resident cells, immune cells, and vascular cells. Reciprocal interactions among these cells are involved in the evolution of the TME. Moreover, the study of attractive therapeutic strategies that target the TME is transitioning from basic research to the clinic. Mouse models are indispensable tools for dissecting the processes and mechanisms leading to TME evolution. In this review, we overview the paradoxical roles of the TME, as well as the recent progress of mouse models in TME research. Finally, we summarize recent advances in TME-targeting therapeutic strategies.
神经胶质瘤在滋养肿瘤细胞的独特而复杂的环境中发展。神经胶质瘤的肿瘤微环境（TME）包含多种异质细胞，包括脑驻留细胞、免疫细胞和血管细胞。这些细胞之间的相互作用涉及 TME 的演变。此外，研究针对 TME 的有吸引力的治疗策略正在从基础研究向临床转化。小鼠模型是解析导致 TME 进化过程和机制的不可或缺的工具。在这篇综述中，我们概述了 TME 的矛盾作用，以及小鼠模型在 TME 研究中的最新进展。最后，我们总结了 TME 靶向治疗策略的最新进展。
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