Kren V, Pazoutová S, Rylko V, Rehácek Z
Folia Microbiol (Praha). 1986;31(4):282-7. doi: 10.1007/BF02926952.
In submerged Claviceps cultures the activity of hydroxymethylglutaryl-CoA reductase preceded the increase of alkaloid production and of sterol content. During the first alkaloid phase, cell mevalonate was involved in the biosynthesis of both alkaloids and steroids. In the second production phase, it was predominantly used for alkaloid synthesis. Hydroxymethylglutaryl-CoA reductase appears to be a suitable target for physiological manipulation to increase clavine alkaloid yields.
在 submerged Claviceps 培养物中，羟甲基戊二酰辅酶 A 还原酶的活性先于生物碱产量和甾醇含量的增加。在第一个生物碱阶段，细胞甲羟戊酸参与生物碱和类固醇的生物合成。在第二个生产阶段，它主要用于生物碱合成。羟甲基戊二酰辅酶 A 还原酶似乎是通过生理调控提高麦角生物碱产量的合适靶点。 （注：submerged Claviceps 这里的 submerged 不太明确准确意思，推测可能是“深层培养的麦角菌”之类意思，你可根据实际专业内容进一步确认。）
