Simpson J A
Muscle Nerve. 1978 Jan-Feb;1(1):45-56. doi: 10.1002/mus.880010107.
A review of our current knowledge of the etiology and pathogenesis of myasthenia gravis is presented, with particular emphasis on the immunological aspects of the disease. Part 1, published in this issue, deals with the clinical and genetic features of myasthenia gravis which led to the autoimmune theory of the etiology of this disease. Various theories in this field are reviewed, and recent advances in our knowledge of the acetylcholine receptor protein, and its immunology, are examined. Part 2, which will appear in the March/April issue, provides a review of the dysfunction of physiology, pharmacology, and structure of the neuromuscular junction in myasthenia gravis, and the part played by the autoimmune process.
本文综述了目前我们对重症肌无力病因和发病机制的认识，特别强调了该疾病的免疫学方面。发表于本期的第1部分讨论了重症肌无力的临床和遗传特征，这些特征促成了该疾病病因的自身免疫理论。对该领域的各种理论进行了综述，并审视了我们在乙酰胆碱受体蛋白及其免疫学知识方面的最新进展。将于3/4月期发表的第2部分综述了重症肌无力中神经肌肉接头的生理、药理和结构功能障碍，以及自身免疫过程所起的作用。
