Modelling Health and Environmental Linkages Research Group (MHELRG), Department of Mathematical and Computational Sciences, University of Venda, Thohoyandou, South Africa.
J Biol Dyn. 2023 Dec;17(1):2255066. doi: 10.1080/17513758.2023.2255066.
Despite the existence of a powerful theoretical foundation for the development of multiscale models of infectious disease dynamics in the form of the replication-transmission relativity theory, the majority of current modelling studies focus more on single-scale modelling. The explicit aim of this study is to change the current predominantly single-scale modelling landscape in the design of planning frameworks for the control, elimination and even eradication of infectious disease systems through the exploitation of multiscale modelling methods based on the application of the replication-transmission relativity theory. We first present a structured roadmap for the development of multiscale models of infectious disease systems. The roadmap is tested on hookworm infection. The testing of the feasibility of the roadmap established a fundamental result which can be generalized to confirm that the complexity of an infectious disease system is encapsulated with a level of organization spanning a microscale and a macroscale.
尽管存在强大的理论基础，即复制-传播相关性理论，用于开发传染病动力学的多尺度模型，但目前大多数建模研究更侧重于单尺度建模。本研究的明确目的是通过利用基于复制-传播相关性理论的多尺度建模方法，改变当前传染病系统控制、消除甚至根除规划框架设计中主要的单尺度建模格局。我们首先为传染病系统的多尺度模型开发提出了一个结构化路线图。该路线图在钩虫感染方面进行了测试。该路线图可行性的测试建立了一个基本结果，可以推广到证实传染病系统的复杂性被封装在一个跨越微观尺度和宏观尺度的组织水平中。
