Gregg P J, Clayton C B, Fenwick J D, Ions G K, Miller S W, Smith S R
Injury. 1986 Mar;17(2):95-103. doi: 10.1016/s0020-1383(86)80005-5.
Eighty patients who had sustained a fracture of the tibial shaft were studied by scintigraphy using technetium-99m labelled methylene diphosphonate (99Tcm MDP) and a gamma camera. Static scintigrams were obtained in the early stages following injury and examined for the presence of 'cold spots' which may indicate loss of blood supply to fracture fragments; these were found in 10 per cent of cases but did not bear any definite relationship to the normal progression of union. Sequential dynamic scintigrams were obtained at intervals up to 20 weeks after fracture to determine whether a pattern of uptake of tracer could be identified which correlated with the subsequent progression of union, but no significant difference was observed between fractures healing promptly (less than 20 weeks) and those in which healing was delayed (greater than 20 weeks).
采用锝-99m标记的亚甲基二膦酸盐（99Tcm MDP）和γ相机对80例胫骨干骨折患者进行了骨闪烁显像研究。在受伤后的早期阶段获取静态骨闪烁显像图，并检查是否存在“冷区”，“冷区”可能提示骨折碎片血供丧失；在10%的病例中发现了“冷区”，但它们与骨折正常愈合进程并无明确关系。在骨折后长达20周的时间间隔内获取连续动态骨闪烁显像图，以确定是否能识别出与随后愈合进程相关的示踪剂摄取模式，但在愈合迅速（少于20周）的骨折与愈合延迟（大于20周）的骨折之间未观察到显著差异。
