Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Adv Protein Chem Struct Biol. 2023;137:1-15. doi: 10.1016/bs.apcsb.2023.02.010. Epub 2023 Aug 28.
The circadian rhythm is the timing mechanism that creates approximately 24-hour rhythms in cellular and bodily functions in almost all living species. These internal clock systems enable living organisms to predict and respond to daily changes in their environment, optimizing temporal physiology and behavior. Circadian rhythms are regulated by both genetic and environmental risk factors. Circadian rhythms play an important role in maintaining homeostasis at the systemic and tissue levels. Disruption of this rhythm lays the groundwork for human health and disease. Disruption in these rhythms increases the susceptibility to many diseases, such as cancer, psychiatric disorders, and neurodegenerative diseases. In this chapter, the characteristics of circadian rhythm and its relationship with diseases will be discussed.
昼夜节律是一种时间机制，它在几乎所有生物的细胞和身体功能中创造了大约 24 小时的节律。这些内部时钟系统使生物体能够预测和应对环境中的日常变化，优化时间生理学和行为。昼夜节律受遗传和环境风险因素的调节。昼夜节律在维持系统和组织水平的内环境稳定方面发挥着重要作用。这种节律的破坏为人类健康和疾病奠定了基础。这些节律的紊乱会增加许多疾病的易感性，如癌症、精神障碍和神经退行性疾病。在本章中，将讨论昼夜节律的特征及其与疾病的关系。
