Department of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, 99202, USA.
Exp Mol Med. 2021 Oct;53(10):1529-1538. doi: 10.1038/s12276-021-00681-0. Epub 2021 Oct 7.
Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h rhythms in cellular and bodily functions across nearly all living species. These internal clock systems enable living organisms to anticipate and respond to daily changes in their environment in a timely manner, optimizing temporal physiology and behaviors. Dysregulation of circadian rhythms by genetic and environmental risk factors increases susceptibility to multiple diseases, particularly cancers. A growing number of studies have revealed dynamic crosstalk between circadian clocks and cancer pathways, providing mechanistic insights into the therapeutic utility of circadian rhythms in cancer treatment. This review will discuss the roles of circadian rhythms in cancer pathogenesis, highlighting the recent advances in chronotherapeutic approaches for improved cancer treatment.
生物钟是普遍存在的计时机制，几乎存在于所有生物的细胞和身体功能中，产生大约 24 小时的节律。这些内部时钟系统使生物体能够及时预测和应对环境中的日常变化，优化时间生理学和行为。遗传和环境风险因素导致的生物钟节律失调会增加多种疾病的易感性，尤其是癌症。越来越多的研究揭示了生物钟与癌症途径之间的动态相互作用，为生物钟在癌症治疗中的治疗效用提供了机制上的见解。这篇综述将讨论生物钟在癌症发病机制中的作用，重点介绍了改善癌症治疗的时间治疗方法的最新进展。
